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公开(公告)号：EP1928496A2
公开(公告)日：2008-06-11
申请号：EP06802602.0
申请日：2006-08-30
申请人： MEDIMMUNE, INC. , Yale University
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/40 , A61K48/00 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C12N9/2442 , C12N15/86 , C12N2710/10343 , C12Y302/01014
摘要： The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL- 13 mediated inflammatory diseases. Accordingly the present invention provides C/CLP antagonists and also provides compositions and methods for the prevention, management, treatment or amelioration of an inflammatory condition associated with the upregulation of a C/CLP or one or more symptoms thereof and/or the inhibition of IL- 13 mediated inflammation.
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公开(公告)号：EP1499352A1
公开(公告)日：2005-01-26
申请号：EP03746713.1
申请日：2003-04-11
发明人： REED, Jennifer, Lynne , DALL'ACQUA, William , VAN SNICK, Jacques , RENAULD, Jean-Christophe , CORMONT, Francoise , UYTTENHOVE, Catherine
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.
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