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    FLUID-ASSISTED ELECTROSURGICAL INSTRUMENT WITH SHAPEABLE ELECTRODE
    3.
    发明公开
    FLUID-ASSISTED ELECTROSURGICAL INSTRUMENT WITH SHAPEABLE ELECTRODE 有权
    液体辅助手术器械电动延展性电极

    公开(公告)号：EP1476093A1

    公开(公告)日：2004-11-17

    申请号：EP03734953.7

    申请日：2003-01-14

    申请人： Medtronic, Inc.

    发明人： OCEL, Jon, M. ,  BRISCOE, Roderick, E. ,  FRANCISCHELLI, David, E. ,  JAHNS, Scott, E. ,  KEOGH, James, R.

    IPC分类号： A61B18/18

    CPC分类号： A61B5/042 ,  A61B5/7475 ,  A61B18/14 ,  A61B2017/2927 ,  A61B2018/1472 ,  A61N1/056

    摘要： An electrosurgical instrument (12, fig. 1) including an elongated shaft (22) and a non-conductive handle (20) is disclosed. The shaft defines a proximal section (40), a distal section (42), and an internal lumen (50) extending from the proximal section. The distal section forms an electrically conductive tip (44) and defines at least one passage (52) for distributing fluid. Further, the shaft is adapted to be transitionable from a straight state to a first bent state (fig. 5). The shaft is capable of independently maintaining the distinct shapes associated with the straight state and the first bent state. The handle is rigidly coupled to the proximal section of the shaft. With this in mind, an exterior surface of the shaft distal the handle and proximal the distal section is electrically non­conductive. In one preferred embodiment, the shaft is comprised of an elongated electrode body surrounded by an electrical insulator.

    OXIDATIVE METHOD FOR ATTACHMENT OF GLYCOPROTEINS OR GLYCOPEPTIDES TO SURFACES OF MEDICAL DEVICES
    8.
    发明公开
    OXIDATIVE METHOD FOR ATTACHMENT OF GLYCOPROTEINS OR GLYCOPEPTIDES TO SURFACES OF MEDICAL DEVICES 有权
    法氧化糖蛋白和糖肽对医疗用品表面约束力

    公开(公告)号：EP1035871A2

    公开(公告)日：2000-09-20

    申请号：EP98960695.9

    申请日：1998-12-03

    申请人： Medtronic, Inc.

    发明人： KEOGH, James, R.

    IPC分类号： A61L2/00

    CPC分类号： A61L31/10 ,  A61L27/28 ,  A61L27/34 ,  A61L29/085 ,  A61L31/08 ,  A61L33/0029 ,  C08L89/00

    摘要： A method for making a medical device having at least one glycoprotein and/or glycopeptide immobilized on a substrate surface is provided. The method may include oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functional material; combining the aldehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and reacting the imine moiety with a reducing agent to form a secondary amine. Another method of the present invention may be employed to crosslink glycoproteins and/or glycopeptides immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink glycoproteins and/or glycopeptides, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.