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1.发明公开MONOCLONAL ANTIBODY INHIBITOR OF GM-CSF, IL-3, IL-5 AND OTHER CYTOKINES, AND USES THEREOF 有权一种单克隆抗体，如GM-CSF的抑制剂，IL-3，IL-5和其它细胞因子及其用途
公开(公告)号：EP1105426A4
公开(公告)日：2002-03-27
申请号：EP99941314
申请日：1999-08-13
发明人： LOPEZ ANGEL , D ANDREA RICHARD
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/73
摘要： A method of isolating a monoclonal antibody capable of inhibiting any one of IL-3, GM-CSF and IL-5 binding to the common receptor beta c, or a monoclonal antibody capable of inhibiting the cytokines binding to a receptor analogous to beta c. The method includes the steps of immunising an animal with a cytokine receptor or portion of a cytokine containing the critical binding site which portion includes the extracellular domain 4 or analogous domain in the analogous common receptor or part thereof. Antibodies producing cells from the animal are then isolated and fused with a myeloma cell line and then screened for a cell line that produces an antibody of the desired type. A monoclonal antibody, or fragments thereof capable of inhibiting the binding of the cytokines IL-3, GM-CSF and IL-5 to the beta c receptor, and a hybridoma cell line producing the antibody are also claimed.
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