-
-
公开(公告)号：EP2791324A4
公开(公告)日：2015-04-29
申请号：EP12856927
申请日：2012-12-13
发明人： LOPEZ ANGEL , SCHWARZ QUENTEN
IPC分类号： C12N5/0793 , A61K45/00 , A61P25/18 , A61P25/28 , C12N5/0797
CPC分类号： A61K35/36 , A61K35/12 , A61K35/30 , A61K35/32 , C12N5/0623
-
公开(公告)号：EP1682571A4
公开(公告)日：2006-12-06
申请号：EP04789620
申请日：2004-10-27
发明人： GUTHRIDGE MARK , RAMSHAW HAYLEY , STOMSKI FRANK , FELQUER FERNANDO , LOPEZ ANGEL
IPC分类号： C07K2/00 , A61K38/00 , A61K38/19 , A61K38/20 , A61P35/00 , A61P43/00 , C07K7/00 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/71 , C07K14/715
CPC分类号： C07K14/435 , A61K38/00 , C07K14/715 , C07K14/7153
摘要： The present invention relates to a novel bidentate motif that is composed of two adjacent residues of tyrosine and serine which have been found to be involved in the binding of crucial cytoplasmic proteins which are involved in cell signalling pathways. In some cases, the cytoplasmic proteins are ubiquitous proteins involved in cell signalling pathways that may include mitogenesis, transformation and survival. The bidentate motif may have a sequence alignment N-X-X-Y- (X) 1-13-[R/K/H/Q]-[X/Psi] 2-3-S/T-X-P; Y- (X) 1-16-[R/K/H/Q]-[X/Psi] 2-3-S/T-X-P; or N-X-X-Y-[X]1-30-[R/K/Q/H]-[X]1-4-[S/T]-X-p wherein X is any residue, Y is tyrosine, S/T is serine or threonine and Y is a hydrophibic residue or an equivalent thereof. Preferably the residues are Tyr577 and Ser585 of the common ßc of the GM-CSF/IL-5/IL-3 receptor.
-
4.发明公开A BINDING MOTIF AND METHODS OF REGULATING CELL FUNCTION 审中-公开BINDUNGSMOTIV UND VERFAHREN ZUR STEUERUNG DER ZELLFUNKTION
公开(公告)号：EP1682570A4
公开(公告)日：2006-12-06
申请号：EP04789618
申请日：2004-10-27
发明人： GUTHRIDGE MARK , RAMSHAW HAYLEY , STOMSKI FRANK , LOPEZ ANGEL
IPC分类号： C07K2/00 , A61K38/00 , A61K38/19 , A61K38/20 , A61P35/00 , A61P43/00 , C07K5/113 , C07K7/06 , C07K14/435 , C07K14/71 , C07K14/715
CPC分类号： C07K5/1021 , A61K38/00 , C07K14/435 , C07K14/715 , C07K14/7153
摘要： The present invention relates to a binding motif and methods of regulating cell function which methods target a single amino acid residue preferably a Tyr in a binding motif equivalent to a motif of the common beta chain (ßc) of the GM-CSF/IL-3/IL-5 receptor. Preferably, the cell functions affect cell survival and proliferation in cells. The methods can be used for treatments of conditions relating to cell survival and proliferation and can be used to expand progenitor cells, for instance, for transplantation purposes.
摘要翻译： 本发明涉及调节细胞功能的结合基序和方法，所述方法靶向与GM-CSF / IL-3的普通β链基序（ßc）相当的结合基序中的单个氨基酸残基，优选Tyr / IL-5受体。 优选地，细胞功能影响细胞的细胞存活和增殖。 该方法可以用于治疗与细胞存活和增殖相关的病症，并且可以用于扩增祖细胞，例如用于移植目的。
-
5.发明公开MONOCLONAL ANTIBODY INHIBITOR OF GM-CSF, IL-3, IL-5 AND OTHER CYTOKINES, AND USES THEREOF 有权一种单克隆抗体，如GM-CSF的抑制剂，IL-3，IL-5和其它细胞因子及其用途
公开(公告)号：EP1105426A4
公开(公告)日：2002-03-27
申请号：EP99941314
申请日：1999-08-13
发明人： LOPEZ ANGEL , D ANDREA RICHARD
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/73
摘要： A method of isolating a monoclonal antibody capable of inhibiting any one of IL-3, GM-CSF and IL-5 binding to the common receptor beta c, or a monoclonal antibody capable of inhibiting the cytokines binding to a receptor analogous to beta c. The method includes the steps of immunising an animal with a cytokine receptor or portion of a cytokine containing the critical binding site which portion includes the extracellular domain 4 or analogous domain in the analogous common receptor or part thereof. Antibodies producing cells from the animal are then isolated and fused with a myeloma cell line and then screened for a cell line that produces an antibody of the desired type. A monoclonal antibody, or fragments thereof capable of inhibiting the binding of the cytokines IL-3, GM-CSF and IL-5 to the beta c receptor, and a hybridoma cell line producing the antibody are also claimed.
-
公开(公告)号：EP0889905A4
公开(公告)日：2000-06-07
申请号：EP97901476
申请日：1997-01-29
发明人： LOPEZ ANGEL , BAGLEY CHRISTOPHER , WOODCOCK JOANNA
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/395 , A61K45/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07K14/705 , C07K14/715 , C07K16/28 , C12Q1/02 , G01N33/566 , C12N15/12
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/70503 , C07K14/715 , C07K14/7153 , C07K14/7155
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.015 秒)
