公开(公告)号：EP1558736A4

公开(公告)日：2006-05-10

申请号：EP03750156

申请日：2003-10-14

申请人： MEDVET SCIENCE PTY LTD

发明人： GAMBLE JENNIFER RUTH ,  VADAS MATHEW ,  PITSON STUART ,  XIA PU ,  LIMAYE VIDYA

IPC分类号： A61K38/45 ,  C12N9/12 ,  C12N15/12 ,  A61K48/00 ,  C12N5/16 ,  C12N15/63

CPC分类号： C12N9/1205 ,  A61K38/45 ,  C12N2799/022

摘要： The present invention relates generally to a method of modulating endothelial cell functional characteristics and to agents useful for same. More particularly, the present invention relates to a method of modulating vascular endothelial cell pro-inflammatory and angiogenic phenotypes by modulating the functional levels of intracellular sphingosine kinase. The method of the present invention is useful, inter alia, in relation to the treatment and/or prophylaxis of conditions which are characterised by inadequate endothelial cell functioning and may include conditions such as vascular engraftment, organ transplantation or wound healing or conditions which are characterised by an aberrant endothelial cell inflammatory or angiogenic phenotype. Further, the method of the present invention facilitates the development of agents, such as functionally manipulated endothelial cell populations, for a range of therapeutic and/or prophylactic uses.

公开(公告)号：EP1545589A4

公开(公告)日：2008-10-29

申请号：EP03793486

申请日：2003-09-05

申请人： MEDVET SCIENCE PTY LTD

发明人： GAMBLE JENNIFER RUTH ,  VADAS MATHEW ALEXANDER ,  XIAOCHUN LI

IPC分类号： A61K31/407 ,  A61K31/4355 ,  A61K38/18 ,  A61P3/04 ,  A61P9/14 ,  A61P27/00 ,  A61P29/00 ,  A61P35/04 ,  A61K38/45

CPC分类号： A61K38/1891 ,  A61K31/407 ,  A61K31/4355