公开(公告)号：EP0730404A1

公开(公告)日：1996-09-11

申请号：EP95901947.0

申请日：1994-11-17

申请人： MEGABIOS CORPORATION

发明人： HEATH, Timothy, D. ,  SOLODIN, Igor

IPC分类号： C12N15 ,  A61K9 ,  A61K47 ,  A61K48 ,  C07C279 ,  C07D233 ,  C07F9 ,  C12N5

CPC分类号： C07D233/56 ,  A61K9/1272 ,  A61K47/6801 ,  C07C279/08 ,  C07F9/10 ,  C12N15/88

摘要： Amphiphiles containing an imidazolinium ring system are provided that are non-toxic to the host mammal. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules intracellularly.

公开(公告)号：EP0730568A1

公开(公告)日：1996-09-11

申请号：EP95904094.0

申请日：1994-11-17

申请人： MEGABIOS CORPORATION

发明人： HEATH, Timothy, D. ,  SOLODIN, Igor

IPC分类号： C12N15 ,  A61K9 ,  A61K47 ,  A61K48 ,  C07D295 ,  C07H21

CPC分类号： C07D295/088 ,  A61K9/1272 ,  C12N15/88

摘要： Novel, heterocyclic cationic amphiphile and compounds thereof are prepared that are degraded in vivo. Liposomes are produced from the cations that are used as carriers for delivering macromolecules intracellularly and may be targeted to a specific cell type.

公开(公告)号：EP0807116A1

公开(公告)日：1997-11-19

申请号：EP94924449.0

申请日：1994-06-22

申请人： MEGABIOS CORPORATION

发明人： HEATH, Timothy, D.

IPC分类号： C07J11 ,  A61K9 ,  C07F9

CPC分类号： A61K9/1271 ,  C07F9/10

摘要： Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The amphiphiles can be used as carriers for delivering macromolecules intracellularly.

公开(公告)号：EP0730405A1

公开(公告)日：1996-09-11

申请号：EP95902642.0

申请日：1994-11-17

申请人： MEGABIOS CORPORATION

发明人： HEATH, Timothy, D. ,  SOLODIN, Igor

IPC分类号： A01K67 ,  A61K9 ,  A61K47 ,  A61K48 ,  C07C279 ,  C12N15

CPC分类号： C12N15/88 ,  A61K9/1272 ,  C07C279/08

摘要： Guanidine-based amphiphiles are provided that are non-toxic to the host mammal, especially a human host. The amphiphiles are used to produce liposomes useful as carriers for delivering macromolecules intracellularly.