公开(公告)号：EP0656368A4

公开(公告)日：1996-05-08

申请号：EP94906771

申请日：1993-08-04

申请人： MEITO SANGYO KK

发明人： HASEGAWA MASAKATSU ,  ITO YOSHIO ,  YAMADA HISATO ,  NAGAE HIDEO ,  TOZAWA NAHOKO ,  HINO YUKARI TAISHI ,  KITO KYOJI ,  HOKUKOKU SHUSABURO ,  LAWACZECK RUDIGER ,  EBERT WOLFGANG ,  PFEFFERER DETLEF ,  WAGNER SUSANNE ,  KRESSE MAYK

IPC分类号： A61K49/04 ,  A61K49/12 ,  A61K49/18 ,  C08B37/02 ,  C08L5/00

CPC分类号： C08L5/00 ,  A61K49/0423 ,  A61K49/126 ,  A61K49/1863 ,  B82Y5/00 ,  C08B37/0021 ,  Y10T436/24

摘要： A composite having a small particle diameter and composed of a water-soluble carboxypolysaccharide and a magnetic iron oxide having a core diameter ranging from about 2 to about 7 nm, wherein the overall diameter ranges from about 10 to about 50 nm, the ratio of the overall diameter to the core diameter is about 15 or less, and the T2 relaxation capacity ranges from about 10 to about 150 (mM.sec)-1. The composite is reduced in toxicity and side effects and is useful as iron preparation, X-ray contrast medium, MRI contrast medium, reagent for blood stream measurement, drug carrier, and so forth in the fields of medicine, biology and engineering.