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公开(公告)号：EP2873677A4
公开(公告)日：2016-04-27
申请号：EP13816363
申请日：2013-07-12
发明人： YOKOI HIDENORI , YOKOYAMA YASUHIRO , MATSUYAMA KEISUKE , YAMAMOTO KENICHIRO , ANZAI KINSEI , NAKAMURA DAISUKE , NAGANO TOYOHIRO , KODAMA KAZUYA
CPC分类号： C07K7/08 , A61K38/00 , C07K5/06043 , C07K5/06095 , C07K5/0808 , C07K5/0819 , C07K7/06
摘要： An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt.
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2.发明公开OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT HAVING AXIAL ASYMMETRY AND PROCESS FOR PRODUCING ALPHA-AMINO ACID AND DERIVATIVE THEREOF WITH THE SAME 审中-公开光有源季铵盐AXIALasymétrieAND METHOD FOR PRODUCING的α-氨基酸和使用它们的衍生物，其
公开(公告)号：EP1870403A4
公开(公告)日：2010-07-07
申请号：EP06730739
申请日：2006-03-24
申请人： NAGASE & CO LTD
IPC分类号： C07D223/18 , B01J31/02 , C07B53/00 , C07B61/00 , C07C227/04 , C07C227/32 , C07C229/36 , C07C249/02 , C07C251/24 , C07D487/10 , C07D498/10 , C07D513/10
CPC分类号： C07B53/00 , B01J31/0239 , B01J2531/985 , C07C227/32 , C07C249/02 , C07D223/18 , C07D487/10 , C07C229/36 , C07C251/24
摘要： The present invention provides a chiral phase-transfer catalyst of the following formula (I): The compound (I) can be produced by reacting a 2,2'-dimethylene bromide-1,1'-biphenyl derivative, which can be produced through comparatively small number of steps, with an easily available secondary amine.
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