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公开(公告)号：EP0930310B1
公开(公告)日：2003-03-26
申请号：EP96917702.1
申请日：1996-06-17
发明人： HIRANO, Shin-ichi , MASE, Toshiyuki , AGATA, Naoki , IGUCHI, Hiroshi , MATSUMOTO, Naoki , YOSHIOKA, Takeo , TONE, Hiroshi , KUMAGAI, Hiroyuki , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
IPC分类号： C07D311/76 , A61K31/35
CPC分类号： C07D311/76
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公开(公告)号：EP1219596A1
公开(公告)日：2002-07-03
申请号：EP00951914.1
申请日：2000-08-09
发明人： TAKEUCHI, Tomio , UMEZAWA, Kazuo , TO-E, Sakino , MATSUMOTO, Naoki , SAWA, Tsutomu , YOSHIOKA, Takeo , AGATA, Naoki , HIRANO, Shin-ichi , ISSHIKI, Kunio
IPC分类号： C07C237/38 , C07C237/40 , C07C231/02 , C07C231/12 , C07D303/22 , C07D303/32 , A61K31/609 , A61P29/00 , A61P37/06 , A61P19/02 , C07D303/14 , A61K31/625
CPC分类号： C07D303/36 , C07C237/38 , C07C237/40
摘要： Salicylamide derivatives represented by formulae (1a) and (1b); intermediates in the production thereof; a process for producing the same; and drugs containing the same as the active ingredient. The salicylamide derivatives represented by formulae (1a) and (1b) are useful as anti-inflammatory agents and immunosuppressive agents which exert an effect of inhibiting the activation of NF-κB with little side effects.
摘要翻译： 由式（1a）和（1b）表示的水杨酰胺衍生物; 中间体在其生产中; 其制造方法; 和含有与活性成分相同的药物。 由式（1a）和（1b）表示的水杨酰胺衍生物可用作具有抑制NF-κB活化的副作用的抗炎剂和免疫抑制剂。
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公开(公告)号：EP0930310A1
公开(公告)日：1999-07-21
申请号：EP96917702.1
申请日：1996-06-17
发明人： HIRANO, Shin-ichi , MASE, Toshiyuki , AGATA, Naoki , IGUCHI, Hiroshi , MATSUMOTO, Naoki , YOSHIOKA, Takeo , TONE, Hiroshi , KUMAGAI, Hiroyuki , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
IPC分类号： C07D311/76 , A61K31/35
CPC分类号： C07D311/76
摘要： Compounds of the formula (I)
wherein R is a hydrogen atom or a C 1-6 alkyl group and n is an integer of 0 or 1, and pharmaceutical preparations thereof are provided. These pharmaceutical preparations are useful for the prevention or treatment of diseases associated with an abnormality in immunological regulatory function or vascularization.
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