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公开(公告)号：EP1124813B1
公开(公告)日：2003-12-03
申请号：EP99955148.4
申请日：1999-10-22
申请人： MERCK & CO., INC.
发明人： STURR, Michael, G. , CHARTRAIN, Michel, M. , HARRIS, Guy, H. , NIELSEN-KAHN, Jennifer , HEIMBUCH, Brian
IPC分类号： C07D309/02 , C07H15/256 , C12P19/44
CPC分类号： C07D309/10
摘要： Biotransformation product of a fermentation with Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
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2.发明公开BIOLOGICAL RESOLUTION OF RACEMIC INDENE OXIDE TO (1S,2R)-INDENE OXIDE 失效FOR RECEMISCHEM茚氧化物ON（1S，2R）分离生物法氧化茚
公开(公告)号：EP0784698A1
公开(公告)日：1997-07-23
申请号：EP95936346.0
申请日：1995-10-17
申请人： MERCK & CO., INC.
摘要： A process is disclosed that hydrolyzes, by the action of an epoxide hydrolase of Diplodia gossipina ATTCC 16391 or ATCC 10936, the undesired enantiomer of racemic indene oxide, an epoxide of indan.
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公开(公告)号：EP1124813A1
公开(公告)日：2001-08-22
申请号：EP99955148.4
申请日：1999-10-22
申请人： MERCK & CO., INC.
发明人： STURR, Michael, G. , CHARTRAIN, Michel, M. , HARRIS, Guy, H. , NIELSEN-KAHN, Jennifer , HEIMBUCH, Brian
IPC分类号： C07D309/02
CPC分类号： C07D309/10
摘要： Biotransformation product of a fermentation with Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
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4.发明公开ENZYMATIC HYDROLYSIS OF 3,3-DIETHYL-4- (4-CARBOXY)PHENOXY]-2-AZETIDINONE ESTERS 失效3,3-二乙基-4-酶解 - （（羧基）苯氧基）-2-氮杂环丁酮酯
公开(公告)号：EP0826065A1
公开(公告)日：1998-03-04
申请号：EP96913261.0
申请日：1996-04-29
申请人： MERCK & CO., INC.
CPC分类号： C12P41/005 , C12P17/10 , Y10S435/875
摘要： The present invention relates to a process for converting a racemic mixture of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters into the corresponding S-acid using lipase derived from Pseudomonas sp. The process provides the target acid in high enantiomeric excess.
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