公开(公告)号：EP4423259A1

公开(公告)日：2024-09-04

申请号：EP22888477.1

申请日：2022-10-26

申请人： Genomatica, Inc.

发明人： SHAH, Amit, Mahendra ,  ZHANG, Deqiang ,  WARNER, Joseph, Roy ,  GRIFFIN, Benjamin, Matthew ,  SHAH, Jinel ,  COLQUITT, Justin, Robert

IPC分类号： C12N9/02 ,  C12N15/63 ,  C12P7/24

CPC分类号： C12N9/0008 ,  C12N9/1096 ,  C12Y206/01 ,  C12N15/52 ,  C12N15/70 ,  C12P7/18 ,  C12P13/001 ,  C12P13/005

公开(公告)号：EP4296364A3

公开(公告)日：2024-08-21

申请号：EP23208030.9

申请日：2014-11-25

申请人： Genomatica, Inc.

发明人： Osterhout, Robin E. ,  Burgard, Anthony P. ,  Pharkya, Priti ,  Andrae, Stefan

IPC分类号： C12N1/19 ,  C12N1/15 ,  C12N1/13 ,  C12N1/11 ,  C12N15/70 ,  C12N15/81 ,  C12P7/42 ,  C12P5/02 ,  C12P13/00 ,  C12P17/10 ,  C12N1/14 ,  C12N1/20 ,  C12P7/02 ,  C12P7/40 ,  C12P7/04 ,  C12P7/44 ,  C12P7/18

CPC分类号： C12N1/14 ,  C12N1/20 ,  C12P7/02 ,  C12P7/18 ,  C12P7/40 ,  C12P7/42 ,  Y02E50/30

摘要： The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA. In some embodiments, the microbial organisms having such pathways also include pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation. The enhanced carbon flux through acetyl-CoA, in combination with pathways for generating reducing equivalents, formaldehyde fixation and/or formate assimilation can, in some embodiments, be used for production of a bioderived compound. Accordingly, in some embodiments, the microbial organisms of the invention can include a pathway capable of producing a bioderived compound of the invention. The invention still further provides a method for producing a bioderived compound of the invention.

公开(公告)号：EP4414451A2

公开(公告)日：2024-08-14

申请号：EP24169292.0

申请日：2014-04-25

申请人： Genomatica, Inc.

发明人： PHARKYA, Priti ,  BURGARD, Anthony P. ,  VAN DIEN, Stephen J. ,  OSTERHOUT, Robin E. ,  BURK, Mark J. ,  TRAWICK, John D. ,  KUCHINSKAS, Michael P. ,  STEER, Brian ,  ANDRAE, Stefan ,  SHAH, Amit

IPC分类号： C12N15/00

CPC分类号： C12P7/24 ,  C12P7/62 ,  C12P17/04 ,  C12N15/52 ,  C12P7/42 ,  C12P13/005 ,  C12P7/18 ,  C12P13/001 ,  C07D307/33 ,  C12N9/13 ,  C12Y208/03

摘要： The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.

公开(公告)号：EP3925997B1

公开(公告)日：2024-07-17

申请号：EP21178711.4

申请日：2006-04-21

IPC分类号： C08G63/16 ,  C08G63/20 ,  C08G63/78 ,  C08L67/02 ,  C08L1/00 ,  C08L5/00 ,  C08L99/00 ,  C12N15/52 ,  C12P7/18 ,  C12P7/44 ,  C12P7/46 ,  C12R1/13 ,  C08L3/00

CPC分类号： C08G63/20 ,  C08G63/78 ,  C08L1/00 ,  C08L3/00 ,  C08L5/00 ,  C08L67/02 ,  C08L99/00 ,  C08L2201/0620130101 ,  C08G63/16 ,  C12P7/18 ,  C12P7/46 ,  C12P7/44 ,  C12R2001/1320210501 ,  C12N15/52 ,  Y02W90/10

公开(公告)号：EP4396334A2

公开(公告)日：2024-07-10

申请号：EP22865701.1

申请日：2022-08-29

申请人： Genomatica, Inc.

发明人： SHAH, Amit Mahendra ,  COLQUITT, Justin Robert ,  NAPOLITANO, Michael Gregory ,  SCHMIDT, Nathan ,  PRAVESCHOTINUNT, Pichet ,  WARNER, Joseph Roy

IPC分类号： C12N9/00 ,  C12Q1/26

CPC分类号： Y02E50/10 ,  C12P7/18 ,  C12Y102/01002 ,  C12N9/0008 ,  C12P19/36

公开(公告)号：EP2334800B1

公开(公告)日：2018-12-26

申请号：EP09813563.5

申请日：2009-09-09

申请人： Genomatica, Inc.

发明人： BURK, Mark, J. ,  BURGARD, Anthony, P. ,  OSTERHOUT, Robin, E. ,  SUN, Jun

IPC分类号： C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12N15/70 ,  C12N15/81 ,  C12P7/18

CPC分类号： C12P7/18 ,  B01D3/002 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/13 ,  C12N9/16 ,  C12N9/88 ,  C12N9/90 ,  C12N9/93 ,  C12N15/52 ,  C12N15/70 ,  C12N15/81 ,  C12Y101/01157 ,  C12Y402/01055

摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.

公开(公告)号：EP3342873A1

公开(公告)日：2018-07-04

申请号：EP16306848.9

申请日：2016-12-29

申请人： Metabolic Explorer

发明人： FAURE, Laetitia ,  BESTEL-CORRE, Gwenaëlle ,  RAYNAUD, Céline ,  DUMON-SEIGNOVERT, Laurence

IPC分类号： C12P7/18 ,  C12P7/26

CPC分类号： C12P7/18 ,  C12P7/26 ,  C12Y101/00

摘要： The present invention relates to new methylglyoxal reductase (MGR) enzymes which are useful for efficiently converting methylglyoxal into hydroxyacetone. The invention more particularly relates to a method for efficiently converting methylglyoxal into hydroxyacetone using said enzymes, to a method for producing 1,2-propanediol using a microorganism overexpressing said enzymes, and to said microorganism.

公开(公告)号：EP3209786A4

公开(公告)日：2018-06-06

申请号：EP15852490

申请日：2015-10-22

申请人： LANZATECH NEW ZEALAND LTD

发明人： TREVETHICK SIMON RICHARD ,  BROMLEY JASON CARL ,  WATERS GUY WILLIAM ,  KOEPKE MICHAEL ,  TRAN LOAN PHUONG ,  JENSEN OVERGAARD RASMUS

IPC分类号： C12P7/06 ,  C12M1/00 ,  C12M3/00 ,  C12P1/00 ,  C12P7/04 ,  C12P7/14 ,  C12P7/18 ,  C12P7/28 ,  C12P7/54

CPC分类号： C12P7/14 ,  C12M23/58 ,  C12M29/18 ,  C12P7/04 ,  C12P7/18 ,  C12P7/28 ,  C12P7/54 ,  Y02E50/17

摘要： Multi-stage, biological processes and systems for converting a C1 carbon source to desired end products are described. The processes comprise dividing a gaseous C1-containing substrate, in parallel, among multiple bioreactor stages. Liquid products are successively fed, in series, from a first bioreactor stage to downstream bioreactor stages. Operation can be simplified by avoiding the requirement for microorganism separation and recycle at each stage. In addition, overall vapor-liquid mass transfer for the combined stages is very favorable, leading to high end product productivity with comparably low byproduct metabolite productivity.

公开(公告)号：EP2811029B1

公开(公告)日：2018-03-21

申请号：EP13743267.0

申请日：2013-01-22

申请人： Asahi Kasei Kabushiki Kaisha

发明人： KONISHI Kazunobu ,  IMAZU Shinichi

IPC分类号： C12P7/02 ,  C12P19/46 ,  C12N1/21 ,  C12N9/04 ,  C12N9/16 ,  C12N9/90

CPC分类号： C07H15/207 ,  C12N9/0006 ,  C12N9/16 ,  C12N9/90 ,  C12P7/02 ,  C12P7/18 ,  C12P19/46 ,  C12Y101/01018 ,  C12Y301/03025 ,  C12Y505/01004 ,  Y02P20/52

摘要： [Problem] To provide a method for industrially producing a scyllo-inositol in a one-step process, from ubiquitous and inexpensive raw materials such as glucose or similar. Furthermore, to provide a new scyllo-inositol derivative obtained by means of said method. [Solution] Scyllo-inositol is produced by one-step fermentation of glucose by a transformed microorganism containing an inositol-1-phosphate synthase gene, an inositol-mono-phosphatase gene, a myo-inositol-dehydrogenase gene and a scyllo-inositol-dehydrogenase gene. Also provided is a scyllo-inositol derivative bonded to saccharides such as glucose and similar, obtained by said fermentation.

公开(公告)号：EP3280694A1

公开(公告)日：2018-02-14

申请号：EP15744646.9

申请日：2015-04-07

申请人： Metabolic Explorer

发明人： SOUCAILLE, Philippe ,  BESTEL-CORRE, Gwénaëlle ,  DUMON-SEIGNOVERT, Laurence

IPC分类号： C07C59/10 ,  C12P7/42

CPC分类号： C12P7/42 ,  C07C31/22 ,  C07C47/19 ,  C07C59/10 ,  C12N9/0004 ,  C12N9/0006 ,  C12P7/18 ,  C12R1/07 ,  C12R1/145 ,  C12R1/19 ,  C12Y101/01001 ,  C12Y102/01003 ,  C12Y102/01004 ,  C12Y102/03001

摘要： The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.