公开(公告)号：EP0877618A1

公开(公告)日：1998-11-18

申请号：EP97906885.0

申请日：1997-01-27

申请人： MERCK & CO., INC.

发明人： SCHWARTZ, Robert, E. ,  BILLS, Gerald, F. ,  GIACOBBE, Robert, A. ,  HORN, Wendy, S. ,  LIESCH, Jerrold, M. ,  MEINZ, Maria, S. ,  MORRIS, Sandra, A. ,  ONISHI, Janet, C. ,  ZINK, Deborah, L. ,  CABELLO, Angeles ,  DIEZ, Teresa ,  MARTIN, Isabella ,  VICENTE, Francisca ,  PELAEZ, Fernando

IPC分类号： C07H15 ,  C12P19

CPC分类号： C12P19/60 ,  C07H15/24

摘要： There is disclosed a novel compound having formula (I) which exhibits antifungal activity.

公开(公告)号：EP0842291A1

公开(公告)日：1998-05-20

申请号：EP96925425.0

申请日：1996-07-22

申请人： MERCK & CO., INC.

发明人： CASCALES, Carmen ,  LINGHAM, Russell, B. ,  PELAEZ, Fernando ,  POLISHOOK, Jon, D. ,  SILVERMAN, Keith, C. ,  SINGH, Sheo, B. ,  ZINK, Deborah, L.

IPC分类号： C12N15 ,  A61K31 ,  A61P35 ,  C07D493 ,  C12N1 ,  C12N9 ,  C12P17 ,  C12R1

CPC分类号： C07D493/04 ,  C12P17/181

摘要： The present invention is directed to non-peptide compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention also relates to the process for the preparation of a compound of this invention by cultivating a culture of Phoma sp. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

摘要翻译： 本发明涉及抑制法尼基蛋白转移酶（FPTase）和癌基因蛋白Ras的法尼基化的非肽化合物。 本发明还涉及通过培养Phoma sp。的培养物来制备本发明化合物的方法。 本发明还涉及含有本发明化合物的化学治疗组合物以及抑制法尼基蛋白转移酶和癌基因蛋白Ras的法尼基化的方法。

公开(公告)号：EP1023281A1

公开(公告)日：2000-08-02

申请号：EP98904970.5

申请日：1998-02-03

申请人： MERCK & CO., INC.

发明人： BILLS, Gerald, F. ,  LINGHAM, Russell, B. ,  SHAFIEE, Ali ,  SILVERMAN, Keith, C. ,  SINGH, Sheo, Bux ,  ZINK, Deborah, L. ,  PELAEZ, Fernando ,  TERAN, Ana M.

IPC分类号： C07D321/00 ,  C07D311/92 ,  A01N43/16 ,  A01N43/02 ,  A61K31/35 ,  A61K31/335 ,  C07D407/10

CPC分类号： C07D405/04 ,  A61K31/495 ,  A61K45/06 ,  C07D311/80 ,  A61K31/365 ,  A61K2300/00

摘要： Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

摘要翻译： 描述了某些天然产物如黄变色素。 这些化合物可用作抑制HIV整合酶，预防或治疗HIV感染和治疗AIDS，作为化合物，药学上可接受的盐，药物组合物成分，不论是否与其他抗病毒剂，免疫调节剂，抗生素或 疫苗。 还描述了治疗AIDS的方法和预防或治疗HIV感染的方法。

公开(公告)号：EP0877618B1

公开(公告)日：2003-01-02

申请号：EP97906885.5

申请日：1997-01-27

申请人： MERCK & CO., INC.

发明人： SCHWARTZ, Robert, E. ,  BILLS, Gerald, F. ,  GIACOBBE, Robert, A. ,  HORN, Wendy, S. ,  LIESCH, Jerrold, M. ,  MEINZ, Maria, S. ,  MORRIS, Sandra, A. ,  ONISHI, Janet, C. ,  ZINK, Deborah, L. ,  CABELLO, Angeles ,  DIEZ, Teresa ,  MARTIN, Isabella ,  VICENTE, Francisca ,  PELAEZ, Fernando

IPC分类号： A61K31/7048 ,  C07H15/24 ,  C12P19/60 ,  C12R1/645

CPC分类号： C12P19/60 ,  C07H15/24

摘要： There is disclosed a novel compound having formula (I) which exhibits antifungal activity.