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1.发明公开Substituted hexahydro arylquinolizines, processes for their preparation and pharmaceutical compositions containing them 失效取代的十六烷基三乙氧基硅烷，其制备方法和含有它们的药物组合物
公开(公告)号：EP0204254A3
公开(公告)日：1988-03-02
申请号：EP86107199
申请日：1986-05-27
申请人： MERCK & CO. INC.
发明人： Baldwin, John J. , Huff, Joel R. , Vacca, Joseph P. , Young, Steven D. , De Solms, Jane , Guare, James P., Jr.
IPC分类号： C07D491/22 , C07D495/22 , C07D513/22 , C07D498/22 , C07D471/20 , C07D471/22 , A61K31/435 , A61K31/505 , A61K31/50 , A61K31/535 , A61K31/55 , C07D307/00 , C07D235/00 , C07D221/00 , C07D231/00
CPC分类号： C07D471/20 , C07D471/22 , C07D491/22 , C07D495/22 , C07D498/22 , C07D513/22
摘要： Substituted hexahydro aryiquinoiizines and pharmaceutically acceptable salts thereof are selective α 2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
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2.发明公开Substituted hexahydro-arylquinolizine derivatives, processes for their preparation and pharmaceutical composition containing them 失效取代Hexahydroarylchinolizinderivate，涉及它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0214556A1
公开(公告)日：1987-03-18
申请号：EP86111890.9
申请日：1986-08-28
申请人： Merck & Co., Inc.
发明人： Huff, Joel R. , Baldwin, John J. , Vacca, Joseph P. , Guare, James P., Jr. , Sakurai, Yojiro MSD(Japan)Co.Ltd.
IPC分类号： C07D491/147 , C07D495/14 , C07D471/14 , C07D455/06 , C07D513/14 , A61K31/435
CPC分类号： C07D471/14 , C07D455/06 , C07D491/14 , C07D495/14
摘要： Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective α 2 -adranergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, antiobesity and platelet aggregation inhibitors and modifiers of gastrointestinal motility.
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3.发明授权Substituted hexahydro-arylquinolizine derivatives, processes for their preparation and pharmaceutical composition containing them 失效取代的四氢呋喃衍生物衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：EP0214556B1
公开(公告)日：1990-11-22
申请号：EP86111890.9
申请日：1986-08-28
申请人： Merck & Co., Inc.
发明人： Huff, Joel R. , Baldwin, John J. , Vacca, Joseph P. , Guare, James P., Jr. , Sakurai, Yojiro MSD(Japan)Co.Ltd.
IPC分类号： C07D491/147 , C07D495/14 , C07D471/14 , C07D455/06 , C07D513/14 , A61K31/435
CPC分类号： C07D471/14 , C07D455/06 , C07D491/14 , C07D495/14
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4.发明公开Substituted hexahydro arylquinolizines, processes for their preparation and pharmaceutical compositions containing them 失效取代Hexahydroarylchinolizine，涉及它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0204254A2
公开(公告)日：1986-12-10
申请号：EP86107199.1
申请日：1986-05-27
申请人： Merck & Co., Inc.
发明人： Baldwin, John J. , Huff, Joel R. , Vacca, Joseph P. , Young, Steven D. , De Solms, Jane , Guare, James P., Jr.
IPC分类号： C07D491/22 , C07D495/22 , C07D513/22 , C07D498/22 , C07D471/20 , C07D471/22 , A61K31/435 , A61K31/505 , A61K31/50 , A61K31/535 , A61K31/55
CPC分类号： C07D471/20 , C07D471/22 , C07D491/22 , C07D495/22 , C07D498/22 , C07D513/22
摘要： Substituted hexahydro aryiquinoiizines and pharmaceutically acceptable salts thereof are selective α 2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
摘要翻译： 取代的六氢arylquinolizines和药学上可接受的盐是选择性α2 - 肾上腺素能受体拮抗剂，并由此作为抗抑郁药，抗高血压药，抗高血压眼，抗糖尿病药，血小板聚集抑制剂，抗肥胖剂，和肠胃蠕动的调节剂是有用的。
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