公开(公告)号：EP0898569A1

公开(公告)日：1999-03-03

申请号：EP97920673.0

申请日：1997-04-14

申请人： MERCK PATENT GmbH

发明人： MÄRZ, Joachim ,  BÖTTCHER, Henning ,  DEVANT, Ralf ,  GREINER, Hartmut ,  BARTOSZYK, Gerd ,  HARTING, Jürgen ,  SEYFRIED, Christoph ,  BENGT, Ronny, Andersson ,  HANSSON, Lars, Olov ,  SONESSON, Clas, Ake ,  STJERNLÖF, Nils, Peter

IPC分类号： C07D211 ,  A61K31 ,  A61P25 ,  A61P43 ,  C07D207 ,  C07D401 ,  C07D403 ,  C07D405

CPC分类号： C07D401/12 ,  A61K9/19 ,  A61K9/2018 ,  A61K9/2059 ,  C07D401/14 ,  C07D405/14

摘要： The invention relates to novel piperidine and pyrrolidine derivatives of formula (I) in which R?1, R2, R3¿, k, l, m and n have the meanings indicated in Claim 1, and their salts, novel intermediates and processes for the preparation of the compounds according to the invention. The compounds of formula (I) act as 5-HT¿1A? receptor antagonists and exhibit 5-HT reuptake-inhibiting actions and can be used for the production of medicaments.