公开(公告)号：EP2770998A4

公开(公告)日：2015-03-18

申请号：EP12843432

申请日：2012-10-24

申请人： MERCK SHARP & DOHME ,  MOCHIDA PHARM CO LTD ,  ALBANY MOLECULAR RES INC

发明人： CHACKALAMANNIL SAMUEL ,  OHKOUCHI MUNETAKA ,  VOSS MATTHEW ,  SONE HIROKI

IPC分类号： A61K31/4412 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/5377 ,  A61P7/02 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/12 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.