公开(公告)号：EP2770998A4

公开(公告)日：2015-03-18

申请号：EP12843432

申请日：2012-10-24

申请人： MERCK SHARP & DOHME ,  MOCHIDA PHARM CO LTD ,  ALBANY MOLECULAR RES INC

发明人： CHACKALAMANNIL SAMUEL ,  OHKOUCHI MUNETAKA ,  VOSS MATTHEW ,  SONE HIROKI

IPC分类号： A61K31/4412 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/5377 ,  A61P7/02 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D401/12 ,  A61K31/4375 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04

摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

公开(公告)号：EP3134408A4

公开(公告)日：2018-01-03

申请号：EP15783339

申请日：2015-04-21

申请人： MERCK SHARP & DOHME

发明人： LIM YEON-HEE ,  GUO ZHUYAN ,  ALI AMJAD ,  EDMONDSON SCOTT D ,  LIU WEIGUO ,  GALLO-ETIENNE GIOCONDA V ,  WU HEPING ,  GAO YING-DUO ,  STAMFORD ANDREW M ,  YU YOUNONG ,  KEVIN NANCY J ,  ANAND RAJAN ,  SHA DEYOU ,  NEELAMKAVIL SANTHOSH F ,  HUSSAIN ZAHID ,  KUMAR PUNEET ,  MONINGKA REMOND ,  DUFFY JOSEPH L ,  XU JIAYI ,  JIANG YU ,  SONE HIROKI ,  CHAKRABARTI ANJAN

IPC分类号： C07D471/10 ,  A61K31/438 ,  C07D498/20

CPC分类号： C07D498/20 ,  C07D471/10 ,  C07D487/10 ,  C07D498/10 ,  C07F9/6561

摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.