公开(公告)号：EP3406594A1

公开(公告)日：2018-11-28

申请号：EP18163465.0

申请日：2013-12-03

申请人： MERCK SHARP & DOHME CORP.

发明人： Bulger, Paul Gerard ,  Kosjek, Birgit ,  Rivera, Nelo

IPC分类号： C07D211/02

CPC分类号： C12P17/12 ,  C07D211/02 ,  C12N9/1096 ,  C12P13/001 ,  C12Y206/01

摘要： A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I :

employing dynamic kinetic resolution (DKR). The DKR process involves an enzymatic enantioselective amination reaction catalyzed by transaminases. The process can be used to manufacture key intermediates in the preparation of poly (ADP-ribose) polymerase (PARP) inhibitors which may be useful for the treatment of cancer.