公开(公告)号：EP1490340A1

公开(公告)日：2004-12-29

申请号：EP03710014.6

申请日：2003-03-21

申请人： MERCK SHARP & DOHME LTD.

发明人： BROWN, Rebecca, Elizabeth ,  DOUGHTY, Victoria, Alexandra ,  HOLLINGWORTH, Gregory, John ,  JONES, A., Brian ,  LINDON, Matthew, John ,  MOYES, Christopher, Richard ,  ROGERS, Lauren

IPC分类号： C07D215/38 ,  C07D215/40 ,  C07D217/22 ,  C07D217/24 ,  C07D217/26 ,  C07D237/28 ,  C07D401/12 ,  C07D401/14 ,  C07D521/00 ,  A61K31/4709 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/501 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D215/38 ,  C07D217/02 ,  C07D217/08 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents, n is 0-3 and y is an aryl, heteroaryl, carbocyclyl or fused-carbocyclyl group; as VR-1 antagonists for treating conditions or diseases in which pain and/or inflammation predominates; the use of the same for manufacturing medicaments, pharmaceutical compositions comprising them and methods of treatment utilising them.