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1.发明授权CYCLOHEXANESULFONYL DERIVATIVES AS GLYT1 INHIBITORS TO TREAT SCHIZOPHRENIA 有权CYCLOHEXANSULFONYLDERIVATE ALS GlyT1抑制剂用于治疗精神分裂症
公开(公告)号：EP1893566B1
公开(公告)日：2013-02-13
申请号：EP06744089.1
申请日：2006-06-05
发明人： BLACKABY, Wesley, Peter Merck & Co., Inc. , CASTRO PINEIRO, Jose, Luis Merck & Co., Inc. , LEWIS, Richard, Thomas Merck & Co., Inc. , NAYLOR, Elizabeth, Mary Merck & Co., Inc. , STREET, Leslie, Joseph
IPC分类号： C07C317/30 , C07D213/82 , C07D239/28 , C07D249/04 , C07C233/70 , A61K31/166 , A61K31/44 , A61K31/4412 , A61K31/4192 , A61P25/18 , C07C233/76 , C07D231/12 , C07D231/18 , C07D307/68 , C07D333/38 , C07D471/04 , C07D495/04 , C07D295/135 , C07D285/125 , C07D295/108
CPC分类号： C07D213/82 , C07C233/70 , C07C233/76 , C07C317/30 , C07C2601/02 , C07C2601/14 , C07D231/12 , C07D231/18 , C07D239/28 , C07D249/04 , C07D285/125 , C07D295/108 , C07D295/135 , C07D307/68 , C07D333/38 , C07D471/04 , C07D495/04
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2.发明授权
公开(公告)号：EP1560580B1
公开(公告)日：2011-01-12
申请号：EP03809792.9
申请日：2003-10-29
发明人： MADIN, Andrew , RIDGILL, Mark Peter
IPC分类号： A61K31/415 , C07D231/12 , C07D401/12 , C07D409/12 , C07D417/12 , A61P25/28
CPC分类号： C07D231/12 , C07D401/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula I inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
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公开(公告)号：EP1831201B1
公开(公告)日：2010-08-04
申请号：EP05821636.7
申请日：2005-12-21
发明人： BLACKABY, Wesley Peter , FLETCHER, Stephen Robert , JENNINGS, Andrew , LEWIS, Richard Thomas , NAYLOR, Elizabeth Mary , STREET, Leslie Joseph , THOMSON, Joanne
IPC分类号： C07D403/12 , C07D401/12 , A61K31/4545 , A61K31/4178 , A61K31/4439 , A61P25/18
CPC分类号： C07D401/14 , C07D401/12 , C07D403/12 , C07D409/14
摘要： The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts thereof, as GlyT1 inhibitors for treating schizophrenia, pharmaceutical compositions comprising the same and methods for their preparation.
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公开(公告)号：EP2001848A1
公开(公告)日：2008-12-17
申请号：EP07733578.4
申请日：2007-03-27
IPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06 , A61K31/435 , A61P25/28
CPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06
摘要： Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions.
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公开(公告)号：EP1603901B1
公开(公告)日：2008-10-15
申请号：EP04717163.2
申请日：2004-03-04
发明人： DIRAT, Olivier , ELLIOTT, Jason Matthew , HUSCROFT, Ian Thomas , JELLEY, Richard Alexander , KULAGOWSKI, Janusz Jozef , RAUBO, Piotr Antoni , SHAW, Duncan Edward , STERNFELD, Francine , SWAIN, Christopher John
IPC分类号： C07D405/04 , C07D405/06 , C07D407/12 , C07D417/04 , C07D491/10 , C07D498/04 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/54 , A61P25/00 , A61P29/00
CPC分类号： C07D405/04 , C07D405/06 , C07D407/12 , C07D417/04 , C07D491/10
摘要： The present invention relates to the compounds of the formula (I), wherein R?1, R2, R3, R4, R5, R6, R7, R8, R9¿ and W are as defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
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公开(公告)号：EP1296940B1
公开(公告)日：2008-07-02
申请号：EP01938439.5
申请日：2001-06-14
IPC分类号： C07C257/14 , C07D333/14 , C07D307/52 , C07D213/36 , A61K31/155 , A61P25/00
CPC分类号： C07D213/40 , C07C257/14 , C07C2601/14
摘要： A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, in particular neuropathic pain and headache, specifically migraine, whils displaying fewer ataxic and related side-effects associated with other classes of NMDA receptor antagonists.
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7.发明授权TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权趋化因子受体活性的四氢环戊TETRAHYDROPYRIDOPYRIDIN调节剂
公开(公告)号：EP1501507B1
公开(公告)日：2008-05-28
申请号：EP03724241.9
申请日：2003-04-25
发明人： JIAO, Richard , MORRIELLO, Gregori , YANG, Lihu , GOBLE, Stephen, D. , MILLS, Sander, G. , PASTERNAK, Alexander , ZHOU, Changyou , BUTORA, Gabor , KOTHANDARAMAN, Shankaran , GUIADEEN, Deodialsingh , TANG, Cheng , MOYES, Christopher
IPC分类号： C07D471/04 , A61K31/4375 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of the formula (I): (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
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公开(公告)号：EP1858852A1
公开(公告)日：2007-11-28
申请号：EP06727159.3
申请日：2006-03-02
IPC分类号： C07D213/24 , C07D213/70 , C07D213/73 , C07D213/79 , C07D333/34 , A61K31/44 , A61P25/00
CPC分类号： C07D213/70 , C07D213/73 , C07D213/79 , C07D213/80 , C07D213/85 , C07D333/34
摘要： Compounds of formula I: are potent and selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of various 10 CNS disorders.
摘要翻译： 式I化合物：是有效的和选择性的5-HT2A受体拮抗剂，因此可用于治疗各种CNS疾病。
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9.发明授权INDAZOL-3-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) 有权吲唑-3-酮和其类似物和衍生物，香草素-1受体（VR1）MODULATE的功能
公开(公告)号：EP1687293B1
公开(公告)日：2007-09-26
申请号：EP04798529.6
申请日：2004-11-12
IPC分类号： C07D401/04 , C07D231/56 , C07D471/04 , A61K31/416 , A61K31/4439 , A61P25/04
CPC分类号： C07D231/56 , C07D401/04 , C07D471/04
摘要： Compounds of formula (I), which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).
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公开(公告)号：EP1819683A2
公开(公告)日：2007-08-22
申请号：EP05852866.2
申请日：2005-12-02
申请人： Merck & Co., Inc. , ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. , MERCK SHARP & DOHME LTD.
发明人： BELYK, Kevin, M. , MORRISON, Henry, G. , JONES, Philip , SUMMA, Vincenzo , COOPER, V., Brett , MAHAJAN, Amar, J. , KUMKE, Daniel, J. , TUNG, Hsien-Hsin , WAI, Lawrence , PRUZINSKY, Vanessa , PYE, Philip , ANGELAUD, Remy , MANCHENO, Danny
IPC分类号： C07D239/557 , C07D413/12 , A61K31/513 , A61P31/18
CPC分类号： C07D239/557 , C07D313/12 , C07D413/12
摘要： Potassium salts of Coompound A and methods for their preparation are disclosed, wherein Compound A is of formula: (Compound A). Compound A is an HIV integrase inhibitor useful for treating or prophylaxis of HIV infection, for delaying the onset of AIDS, and for treating or prophylaxis of AIDS.
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