公开(公告)号：EP1254108A1

公开(公告)日：2002-11-06

申请号：EP01901274.9

申请日：2001-01-19

申请人： MERCK SHARP & DOHME LTD.

发明人： CASTRO PINEIRO,Jose,Luis,Terlings Park ,  HARRISON, Timothy ,  HUNT, Peter, Alan ,  NADIN, Alan, John

IPC分类号： C07C271/22 ,  C07D243/10 ,  C07K5/02 ,  A61K31/27 ,  A61P25/28

CPC分类号： C07D243/14 ,  A61K38/00 ,  C07K5/0207

摘要： Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are diastereoisomers of known protease inhibitors.

公开(公告)号：EP1644346A1

公开(公告)日：2006-04-12

申请号：EP04731671.6

申请日：2004-05-07

申请人： MERCK SHARP & DOHME LTD.

发明人： DINNELL, Kevin ,  HARRISON, Timothy ,  NADIN, Alan, John ,  OWENS, Andrew, Pate ,  SHAW, Duncan, Edward ,  WILLIAMS, Brian, John

IPC分类号： C07D285/16 ,  C07D513/04 ,  C07D279/02 ,  A61K31/5415

CPC分类号： C07D279/02

摘要： Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.