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1.发明公开BICYCLIC, SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开双环取代的三唑AS PPAR调节剂及其制备方法
公开(公告)号：EP1749000A2
公开(公告)日：2007-02-07
申请号：EP05754233.4
申请日：2005-05-24
申请人： METABOLEX, INC.
发明人： ZHU, Yan , MA, Jingyuan , CHENG, Peng , ZHAO, Zuchun , GREGOIRE, Francine M. , RAKHMANOVA, Vera A.
IPC分类号： C07D403/12
CPC分类号： C07D403/12 , C07D403/06 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
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2.发明公开SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION 审中-公开AS PPAR调节取代的三唑及其制造方法
公开(公告)号：EP1751120A2
公开(公告)日：2007-02-14
申请号：EP05759611.6
申请日：2005-05-24
申请人： METABOLEX, INC.
发明人： ZHU, Yan , MA, Jingyuan , CHENG, Peng , ZHAO, Zuchun , GREGOIRE, Francine M. , RAKHMANOVA, Vera A.
IPC分类号： C07D249/06 , A01N43/647
CPC分类号： C07D249/06 , C07D409/10
摘要： The present invention is directed to certain novel triazole compounds represented by Formula: (I); and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
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公开(公告)号：EP2346498A1
公开(公告)日：2011-07-27
申请号：EP09821200.4
申请日：2009-10-14
申请人： Metabolex Inc.
IPC分类号： A61K31/09
CPC分类号： A61K31/192 , A61K31/09 , A61K31/4015
摘要： The present invention provides methods for increasing LDL particle size.
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