利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.008 秒)

    Therapeutic IgM concentrates
    1.
    发明公开
    Therapeutic IgM concentrates 失效
    治疗性IGM浓度

    公开(公告)号：EP0345543A3

    公开(公告)日：1990-06-13

    申请号：EP89109372.6

    申请日：1989-05-24

    申请人： MILES INC.

    发明人： Collins, Michael S. ,  Opitz, Hans Georg ,  Lundblad, John L. ,  Seng, Richard L.

    IPC分类号： A61K39/395

    CPC分类号： C07K16/1203 ,  A61K38/00

    摘要： Protective antibody compositions comprising at least 33% by weight of antibodies of the IgM type and substantially free of homologous isoagglutinins are highly active against gram negative pathogens in mammals. Such compositions are preferably polyclonal and prepared from human plasma, or may be a formulation of different monoclonal antibodies. A very preferred IgM content is at least 50% by weight and the isoagglutinin titer is less than about 1:4. In one embodiment, the compositions are prepared in a lyophilized form such that, upon aqueous reconstitution, they result in a solution having a pH ranging from about 4.0 to 8.0, preferably 4.0 to 7.0 and can be administered intravenously.

    Therapeutic IgM concentrates
    2.
    发明公开
    Therapeutic IgM concentrates 失效
    治疗IgM-Konzentrate。

    公开(公告)号：EP0345543A2

    公开(公告)日：1989-12-13

    申请号：EP89109372.6

    申请日：1989-05-24

    申请人： MILES INC.

    发明人： Collins, Michael S. ,  Opitz, Hans Georg ,  Lundblad, John L. ,  Seng, Richard L.

    IPC分类号： A61K39/395

    CPC分类号： C07K16/1203 ,  A61K38/00

    摘要： Protective antibody compositions comprising at least 33% by weight of antibodies of the IgM type and substantially free of homologous isoagglutinins are highly active against gram negative pathogens in mammals. Such compositions are preferably polyclonal and prepared from human plasma, or may be a formulation of different monoclonal antibodies. A very preferred IgM content is at least 50% by weight and the isoagglutinin titer is less than about 1:4. In one embodiment, the compositions are prepared in a lyophilized form such that, upon aqueous reconstitution, they result in a solution having a pH ranging from about 4.0 to 8.0, preferably 4.0 to 7.0 and can be administered intravenously.

    摘要翻译： 包含至少33重量％的IgM型抗体并基本上不含同源异凝集素的保护性抗体组合物对哺乳动物中的革兰氏阴性病原体具有高度活性。 这样的组合物优选为多克隆并由人血浆制备，或可以是不同单克隆抗体的制剂。 非常优选的IgM含量为至少50重量％，异凝集素滴度小于约1:4。 在一个实施方案中，组合物以冻干形式制备，使得在水重构时，它们产生pH范围为约4.0至8.0，优选4.0至7.0的溶液，并且可以静脉内施用。