公开(公告)号：EP3387439A1

公开(公告)日：2018-10-17

申请号：EP16806079.6

申请日：2016-12-05

申请人： F. Hoffmann-La Roche AG

发明人： MOLHOJ, Michael ,  GASSNER, Christian ,  MOELLEKEN, Joerg ,  ENDESFELDER, Manuel

IPC分类号： G01N33/569 ,  G01N33/53 ,  G01N33/536

CPC分类号： G01N33/557 ,  C07K16/00 ,  C07K16/1203 ,  C07K16/22 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/92 ,  C12Q1/37 ,  G01N21/553 ,  G01N33/5375 ,  G01N33/566 ,  G01N33/56911 ,  G01N33/56955 ,  G01N33/6857 ,  G01N2333/96466

摘要： Herein is reported a method for determining the binding affinity of the binding sites of a bivalent full length antibody of the human IgG1 subclass to a homo-multimeric antigen comprising the steps of i) incubating a mixture comprising the antibody and a polypeptide that is derived from lysine-gingipain of porphyromonas gingivalis at a pH of from pH 7.5 to pH 8.5, in the presence of a reducing agent, at a temperature of from 30° C. to 42° C., for time of from 10 min. to 240 min. to cleave the antibody into Fabs and Fc-region, and ii) determining the binding affinity of the Fabs of the antibody for its antigen using a surface plasmon resonance method by directly applying the incubated reaction mixture obtained in the previous step in the surface plasmon resonance method and therewith determining the binding affinity of the binding sites of the bivalent full length antibody of the human IgG1 subclass.

公开(公告)号：EP3352786A1

公开(公告)日：2018-08-01

申请号：EP16775844.0

申请日：2016-09-23

申请人： The Secretary of State for Health

发明人： VIPOND, Julia ,  BEWLEY, Kevin

IPC分类号： A61K39/02 ,  A61K38/16 ,  C07K14/195

CPC分类号： A61K39/0208 ,  A61K45/06 ,  A61K2039/575 ,  C07K14/195 ,  C07K14/29 ,  C07K16/1203 ,  G01N33/56911

摘要： The present invention provides antigens, for use in the treatment or prevention of C. burnetii infection. Also provided are nucleic acids encoding such antigens, and antibodies raised against such antigens.

公开(公告)号：EP2789632B1

公开(公告)日：2018-06-06

申请号：EP12854873.2

申请日：2012-12-10

申请人： Protein Design Lab, Ltd.

发明人： QIU, Xiaoqing

IPC分类号： C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  A61K39/395 ,  A61P31/00

CPC分类号： B01J19/0046 ,  A61K39/395 ,  B01J2219/00583 ,  B01J2219/00725 ,  C07K14/21 ,  C07K14/245 ,  C07K16/00 ,  C07K16/085 ,  C07K16/1203 ,  C07K2317/73 ,  C07K2319/00 ,  G01N33/569 ,  G01N2500/04

摘要： Provided are a novel antibiotic preparation method and platform system based on the method, belonging to a novel drug development method. The method is based on a fixed structural formula: F-R, wherein F is an effect area, and R is an identification area. At the prior art level, the present invention can quickly develop a specific novel antibiotic for most pathogenic microorganisms or biological cells. Also provided is a platform for implementing the method, ensuring that the novel antibiotic is developed in an efficient streamlined process.

公开(公告)号：EP3049437A1

公开(公告)日：2016-08-03

申请号：EP14772115.3

申请日：2014-09-22

申请人： F.Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： SCHRAEML, Michael ,  CASAGOLDA VALLRIBERA, David ,  KRONER, Frank

IPC分类号： C07K16/12

CPC分类号： C07K16/1203 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N33/577

摘要： The present description relates to anti-Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.

公开(公告)号：EP2943217A1

公开(公告)日：2015-11-18

申请号：EP13821811.0

申请日：2013-12-18

申请人： Institute of Technology, Tallaght

发明人： MCCLEAN, Siobhan ,  SHINOY, Minu

IPC分类号： A61K39/00

CPC分类号： A61K39/02 ,  A61K39/104 ,  A61K45/06 ,  A61K2039/53 ,  A61K2039/55505 ,  C07K16/1203

摘要： An agent for use in a vaccine therapy to prevent or treat a Burkholderia infection in a mammal, wherein the agent is selected from a polypeptide of SEQUENCE ID NO:1, or a therapeutically effective variant thereof having at least 90% sequence identity with SEQUENCE ID NO: 1; a polypeptide of SEQUENCE ID NO:3, or a therapeutically effective variant thereof having at least 90% sequence identity with SEQUENCE ID NO: 3; and an immunogenic portion of the polypeptides of SEQUENCE ID NO:1 or SEQUENCE ID NO:3.

公开(公告)号：EP2336174B8

公开(公告)日：2015-09-23

申请号：EP10180621.4

申请日：2005-11-04

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： Dimitrov, Diviter S ,  Zhu, Zhongyu ,  Broder, Christopher C

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

公开(公告)号：EP1655607B1

公开(公告)日：2015-05-13

申请号：EP05023398.0

申请日：1996-06-05

申请人： BOEHRINGER INGELHEIM VETMEDICA, INC.

发明人： Knittel, Jeffrey P. ,  Roof, Michael B.

IPC分类号： G01N33/554 ,  A61K39/02 ,  C12Q1/02 ,  C12N1/36 ,  C12N1/20

CPC分类号： C12R1/01 ,  A61K39/105 ,  A61K2039/521 ,  A61K2039/522 ,  A61K2039/552 ,  C07K16/1203 ,  C12N1/20 ,  G01N33/56911 ,  G01N33/56922 ,  G01N2333/195 ,  G01N2469/20 ,  Y10S424/825

公开(公告)号：EP2789632A1

公开(公告)日：2014-10-15

申请号：EP12854873.2

申请日：2012-12-10

申请人： Protein Design Lab, Ltd.

发明人： QIU, Xiaoqing

IPC分类号： C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  A61K39/395 ,  A61P31/00

CPC分类号： B01J19/0046 ,  A61K39/395 ,  B01J2219/00583 ,  B01J2219/00725 ,  C07K14/21 ,  C07K14/245 ,  C07K16/00 ,  C07K16/085 ,  C07K16/1203 ,  C07K2317/73 ,  C07K2319/00 ,  G01N33/569 ,  G01N2500/04

摘要： Provided are a novel antibiotic preparation method and platform system based on the method, belonging to a novel drug development method. The method is based on a fixed structural formula: F-R, wherein F is an effect area, and R is an identification area. At the prior art level, the present invention can quickly develop a specific novel antibiotic for most pathogenic microorganisms or biological cells. Also provided is a platform for implementing the method, ensuring that the novel antibiotic is developed in an efficient streamlined process.

摘要翻译： 提供了一种基于该方法的新型抗生素制备方法和平台体系，属于新型药物开发方法。 该方法基于固定结构式：F-R，其中F是效应区域，R是识别区域。 在现有技术水平上，本发明可以快速开发出大多数致病微生物或生物细胞的特异性新型抗生素。 还提供了一种实施该方法的平台，确保新型抗生素在有效的流程化过程中开发。

公开(公告)号：EP2712618A1

公开(公告)日：2014-04-02

申请号：EP13191266.9

申请日：2007-06-20

申请人： EnGeneIC Molecular Delivery Pty Ltd.

发明人： Brahmbhatt, Himanshu ,  Macdiarmid, Jennifer

IPC分类号： A61K35/74 ,  A61K31/7105 ,  A61K31/713 ,  A61K31/7088 ,  A61K31/711 ,  A61P35/00

CPC分类号： A61K47/46 ,  A61K31/337 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K47/6849 ,  A61K47/6901 ,  A61K48/00 ,  A61K48/0008 ,  A61K2039/505 ,  C07K16/1203 ,  C07K16/1235 ,  C07K16/2863 ,  C07K2317/31 ,  Y02A50/481

摘要： A composition comprising intact killed bacterial cells that contain a therapeutic nucleic acid, a drug or a functional nucleic acid is useful for targeted delivery to mammalian cells. The targeted delivery optionally employs bispecific ligands, comprising a first arm that carries specificity for a killed bacterial cell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target killed bacterial cells to specific mammalian cells and to cause endocytosis of the killed bacterial cells by the mammalian cells. Alternatively, the delivery method exploits the natural ability of phagocytic mammalian cells to engulf killed bacterial cells without the use of bispecific ligands.

摘要翻译： 包括完整灭活细菌细胞的组合物的确含有治疗性核酸，药物或功能性核酸是用于靶向递送至哺乳动物细胞中是有用的。 靶向递送任选使用的双特异性配体，其包括第一臂确实携带特异性杀死的细菌细胞表面结构和第二臂确实携带特异性哺乳动物细胞表面受体，以杀死细菌细胞定位到特定的哺乳动物细胞并引起的内吞 由哺乳动物细胞杀死细菌细胞。 可替代地，递送方法利用吞噬哺乳动物细胞的吞噬杀死细菌细胞，而无需使用双特异性配体的天然能力。

公开(公告)号：EP2705147A1

公开(公告)日：2014-03-12

申请号：EP12720476.6

申请日：2012-05-04

申请人： F. Hoffmann-La Roche AG

发明人： ANDRES, Herbert ,  CASAGOLDA VALLRIBERA, David ,  DUEFEL, Hartmut ,  GERG, Michael ,  SCHOLZ, Christian ,  SCHRAEML, Michael

IPC分类号： C12N9/90 ,  C07K14/195 ,  C07K14/415 ,  C07K14/47 ,  C07K16/22

CPC分类号： C07K16/22 ,  C07K14/475 ,  C07K14/65 ,  C07K16/1203 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/23 ,  C07K2319/24 ,  C07K2319/35 ,  C07K2319/41 ,  C07K2319/43 ,  C12N9/90 ,  C12Y502/01008 ,  G01N33/573 ,  G01N33/74 ,  G01N2333/99

摘要： Herein is reported a fusion polypeptide according to formula (I): NH2—S2—X1—S1—COOH, wherein X1 comprises either a random amino acid sequence or an amino acid sequence derived from a first polypeptide, S2 and S1 are non-overlapping amino acid sequences derived from a second polypeptide, and denotes a peptide bond, wherein the second polypeptide is a polypeptide with peptidyl-prolyl cis/trans-isomerase activity (PPIase activity) or is derived from the FKBP-fold domain family, wherein X1 is inserted in place of the insert-in-flap-domain of the second polypeptide.

摘要翻译： 本文报道了根据式（I）的融合多肽：NH2-S2-X1-S1-COOH，其中X1包含随机氨基酸序列或衍生自第一多肽的氨基酸序列，S2和S1不重叠 衍生自第二多肽的氨基酸序列，并且表示肽键，其中第二多肽是具有肽基 - 脯氨酰顺/反异构酶活性（PPIase活性）或衍生自FKBP-折叠域家族的多肽，其中X1是 插入第二多肽的插入片段结构域。