公开(公告)号：EP3191145A1

公开(公告)日：2017-07-19

申请号：EP15767389.8

申请日：2015-09-08

申请人： MiMedx Group, Inc.

发明人： MCQUEEN, Adam ,  BURROWS, Frank ,  KOOB, Thomas

IPC分类号： A61L26/00

CPC分类号： A61K35/50 ,  A61L26/0014 ,  A61L26/0019 ,  A61L26/0057 ,  A61L26/0076 ,  A61L26/008 ,  A61L26/0095

摘要： Described herein are compositions composed of micronized placental components and optionally a sealant, and pharmaceutical compositions thereof. Also described are systems, apparatuses, and methods for applying the combination of micronized placental components and optionally a sealant (e.g., adhesive or gelation agent) for wound care and other medical applications.

摘要翻译： 本文描述了由微粉化的胎盘组分和任选的密封剂组成的组合物及其药物组合物。 还描述了用于将用于伤口护理和其他医学应用的微粉化胎盘组分和粘合剂（可选地，密封剂（例如粘合剂或凝胶剂））的组合应用的系统，装置和方法。

公开(公告)号：EP3167049A1

公开(公告)日：2017-05-17

申请号：EP15819525.5

申请日：2015-07-07

申请人： MIMEDX Group Inc.

发明人： SPENCER, Randall ,  SITH, Somaly ,  KOOB, Thomas

IPC分类号： C12N5/073 ,  A61K35/50 ,  A61L27/38

CPC分类号： A61K35/51 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/16 ,  C12N5/065 ,  C12N2509/10

摘要： Provided are compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste and administered topically or injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized.

摘要翻译： 本发明提供具有控制粘度的微粉化沃顿粘胶的组合物和制剂，使得当递送到受试者的受伤部位时，其基本上保持局部化，很少或没有从受伤部位迁移出来用于其修复和/或再生。 微粉化的沃顿的果冻可以悬浮在药学上可接受的水性载体例如盐水，无菌水或任何合适的缓冲液中以形成悬浮液或凝胶状凝胶组合物，或者其可以呈糊状形式，适合于递送到 与受试者的关节面软骨损伤区域相邻的空间。 当以足够的浓度使用时，微粉化的沃顿果冻可以被水合成凝胶或糊状物并局部给药，或者可以通过使用针头和注射器将其注射到体内。 因此，可以按照比根据本发明未微粉化的沃顿胶冻更方便的方式来输送微粉化的沃顿胶冻，组合物或其制剂。