公开(公告)号：EP1642881A4

公开(公告)日：2007-07-18

申请号：EP04747165

申请日：2004-07-01

申请人： MITSUBISHI GAS CHEMICAL CO

发明人： YOSHIMURA T ,  HIDAKA T ,  SATO Y ,  FUSHIMI N ,  YAMADA KAZUHIRO

IPC分类号： C07C51/363 ,  C07C63/70

CPC分类号： C07C51/363 ,  C07C63/70

摘要： A process for producing 5-iodo-2-methylbenzoic acid by iodizing 2-methylbenzoic acid, which comprises, as essential steps, a reaction step in which 2-methylbenzoic acid is iodized in the presence of a microporous compound, iodine, an oxidizing agent, and acetic anhydride and a purification step in which sublimation, distillation, crystallization, or a combination of two or more of these is conducted. By the process, 5-iodo-2-methylbenzoic acid, which is useful in functional chemicals such as medicines, can be easily obtained as a high-purity compound in a high yield. The production steps comprising reaction and separation/purification are simple from the standpoint of process operation and the purification load is small. Furthermore, the microporous compound, e.g., a zeolite catalyst, separated and recovered from the liquid resulting from the reaction can be repeatedly used after a simple treatment. Consequently, the catalyst has a long life and the target compound can be produced by the efficient process.

公开(公告)号：EP1777215A4

公开(公告)日：2008-09-03

申请号：EP05768520

申请日：2005-08-03

申请人： MITSUBISHI GAS CHEMICAL CO

发明人： YAMADA KAZUHIRO ,  FUSHIMI NORIO

IPC分类号： C07C227/16 ,  C07C229/56

CPC分类号： C07C227/16 ,  C07C229/56

摘要： Disclosed is a method for producing 2-amino-5-iodobenzoic acid wherein 2-aminobenzoic acid (A) and a molecular iodine (B) are reacted in a liquid phase in the presence of an oxidant. Hydrogen peroxide is preferably used as the oxidant. This method does not require a step for refining 2-amino-5-iodobenzoic acid or a step for recovering iodine, and enables to economically advantageously produce high-quality 2-amino-5-iodobenzoic acid with high yield. The thus-produced 2-amino-5-iodobenzoic acid can be advantageously used as a pharmaceutical intermediate, an agricultural chemical, a raw material for functional chemicals or the like.