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    METHOD OF PREPARING AND RECOVERING 2-METHYL-5-IODOBENZOIC ACID
    3.
    发明公开
    METHOD OF PREPARING AND RECOVERING 2-METHYL-5-IODOBENZOIC ACID 审中-公开
    VERFAHREN ZUR HERSTELLUNG UNDRÜCKGEWINNUNGVON 2-METHYL-5-IODOBENZOESÄURE

    公开(公告)号：EP3059220A4

    公开(公告)日：2017-06-14

    申请号：EP13895696

    申请日：2013-10-18

    申请人： ABA CHEMICALS CORP

    发明人： LIN ZHIGANG ,  LI HANG ,  XU JUN ,  QUE LIMIN ,  QIN DONGGUANG ,  JIANG YUEHENG

    IPC分类号： C07C51/363 ,  C07C63/70

    CPC分类号： C07C51/363 ,  C07C63/70

    摘要： Provided is a method of preparing and recovering 2-methyl-5-iodobenzoic acid. The method utilizes o-methylbenzoic acid as raw material, iodinating via iodine/potassium persulfate in a mixed acid solvent to obtain a mixture of 2-methyl-5-iodobenzoic acid, 2-methyl-3-iodobenzoic acid, and 2-methyl-3, 5-diiodobenzoic acid; refining to obtain 2-methyl-5-iodobenzoic acid and recoverable mother liquor, the recoverable mother liquor being a mixture of 2-methyl-5-iodobenzoic acid, 2-methyl-3-iodobenzoic acid, and 2-methyl-3, 5-diiodobenzoic acid; conducting catalytic hydrogenation and deiodination to recover o-methylbenzoic acid and iodide ions; and oxidating the iodide ions to recover iodine. The whole process is recycled. The preparation and recovery method has cheap and easily available raw materials, and is easy of operation, has low requirements for equipment, and is suitable for large-scale industrial production.

    摘要翻译： 提供了一种制备和回收2-甲基-5-碘苯甲酸的方法。 该方法以邻甲基苯甲酸为原料，通过碘/过硫酸钾在混合酸溶剂中碘化，得到2-甲基-5-碘苯甲酸，2-甲基-3-碘苯甲酸和2-甲基-3-碘苯甲酸的混合物， 3,5-二碘苯甲酸; 精制以获得2-甲基-5-碘苯甲酸和可回收母液，所述可回收母液为2-甲基-5-碘苯甲酸，2-甲基-3-碘苯甲酸和2-甲基-3,5 - 二碘苯甲酸; 进行催化氢化和脱碘以回收邻甲基苯甲酸和碘离子; 并氧化碘离子以回收碘。 整个过程被回收。 该制备和回收方法原料廉价易得，操作简单，对设备要求低，适合大规模工业化生产。

    5-BROMINE-2-(alpha-HYDROXYPENTYL)BENZOIC ACID SODIUM SALTS IN DIFFERENT CRYSTAL FORMS, AND PREPARATION METHOD THEREOF
    4.
    发明公开
    5-BROMINE-2-(alpha-HYDROXYPENTYL)BENZOIC ACID SODIUM SALTS IN DIFFERENT CRYSTAL FORMS, AND PREPARATION METHOD THEREOF 审中-公开
    5-BROMIN-2-（ALPHA-HYDROXYPENTYL）BENZOESUREURE NATRIUMSALZE IN VERSCHIEDENEN KRISTALLFORMEN UND HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP3023410A4

    公开(公告)日：2017-02-08

    申请号：EP14826150

    申请日：2014-07-10

    申请人： ZHEJIANG AUSUN PHARMACEUTICAL CO LTD

    发明人： CHANG JUNBIAO ,  SONG CHUANJUN

    IPC分类号： C07C65/03 ,  A61K31/192 ,  C07C51/09

    CPC分类号： C07C63/70 ,  C07B2200/13 ,  C07C51/09 ,  C07C51/60 ,  C07C65/03

    摘要： The present invention discloses 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt in different crystal forms and the preparation methods thereof, and belongs to the field of pharmaceutical chemistry. Said different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt include: amorphous 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, crystal form A of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, and crystal form B of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt. The different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt obtained according to the present invention have better stability and water-solubility than the mixed forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt, thus is advantageous for pharmaceutical use. Moreover, the different crystal forms of 5-bromo-2-(±-hydroxypentyl)benzoic acid sodium salt possess much better therapeutic effect than 5-bromo-2-(±-hydroxypentyl)benzoic acid potassium salt.

    摘要翻译： 本发明公开了不同晶型的5-溴-2-（± - 羟基戊基）苯甲酸钠盐及其制备方法，属于药物化学领域。 所述不同晶型的5-溴-2-（± - 羟基戊基）苯甲酸钠盐包括：无定形5-溴-2-（± - 羟基戊基）苯甲酸钠盐，5-溴-2-（ ± - 羟基戊基）苯甲酸钠盐和5-溴-2-（± - 羟基戊基）苯甲酸钠盐的晶型B. 根据本发明获得的5-溴-2-（± - 羟基戊基）苯甲酸钠盐的不同晶体形式比5-溴-2-（± - 羟基戊基）苯甲酸的混合形式具有更好的稳定性和水溶性 酸性钠盐，因此对于药物使用是有利的。 此外，5-溴-2-（± - 羟基戊基）苯甲酸钠盐的不同晶体形式具有比5-溴-2-（± - 羟基戊基）苯甲酸钾盐好得多的治疗效果。

    METHOD FOR PRODUCING PENTAFLUOROSULFANYL BENZOIC ACID
    8.
    发明公开
    METHOD FOR PRODUCING PENTAFLUOROSULFANYL BENZOIC ACID 有权
    生产五氟磺酸苯甲酸的方法

    公开(公告)号：EP2789603A1

    公开(公告)日：2014-10-15

    申请号：EP12855616.4

    申请日：2012-12-04

    申请人： Ube Industries, Ltd.

    发明人： SAITO, Norimichi ,  CHIKA, Junichi

    IPC分类号： C07C381/00

    CPC分类号： C07C51/04 ,  C07C63/70 ,  C07C381/00

    摘要： Provided is a simple, safe, and industrially practical method for producing a pentafluorosulfanylbenzoic acid.
    This method includes (A) a providing step of providing a trihalomethyl(pentafluorosulfanylbenzene) represented by general formula (1):

    where X is a halogen atom, n is an integer of 1 ≤ n ≤ 3, and the hydrogen atoms on the benzene ring are optionally replaced with a group having an oxygen atom, a group having a nitrogen atom, or a halogen atom;
    (B1) a step of reacting the trihalomethyl(pentafluorosulfanylbenzene) with a carboxylic acid, water, or a disiloxane represented by general formula (b):

            R 3 Si-O-SiR 3      (b)

    (where R 3 is an alkyl group)
    in the presence of an acid other than carboxylic acids to form a pentafluorosulfanylbenzoic halide represented by general formula (2a):

    where X and n are as defined above, and the hydrogen atoms on the benzene ring are optionally replaced with the group or atom defined above; and
    (B2) a step of converting the pentafluorosulfanylbenzoic halide into a pentafluorosulfanylbenzoic acid represented by general formula (2):

    where n is as defined above, and the hydrogen atoms on the benzene ring are optionally replaced with the group or atom defined above.

    摘要翻译： 提供了一种用于生产五氟硫烷基苯甲酸的简单，安全且工业上实用的方法。 该方法包括（A）提供步骤，提供由通式（1）表示的三卤代甲基（五氟硫烷基苯）：其中X是卤素原子，n是1≤n≤3的整数，并且苯环上的氢原子 任选被具有氧原子，具有氮原子的基团或卤原子的基团取代; （B1）使三卤甲基（五氟硫烷基苯）与通式（b）所示的羧酸，水或二硅氧烷反应的步骤：R3Si-O-SiR3（b）（R3为烷基） （2a）表示的五氟硫烷基苯甲酰卤化物：其中X和n如上所定义，并且苯环上的氢原子任选被上述定义的基团或原子置换; （B2）将五氟硫烷基苯甲酰卤转化为通式（2）表示的五氟硫烷基苯甲酸的步骤：其中n如上所定义，并且苯环上的氢原子任选地被以上定义的基团或原子置换。

    METHODS FOR MAKING ORGANOZINC SALTS AND COMPOSITIONS CONTAINING THE SAME
    9.
    发明公开
    METHODS FOR MAKING ORGANOZINC SALTS AND COMPOSITIONS CONTAINING THE SAME 审中-公开
    用于生产ORGANOZINKSALZEN和组合物SO

    公开(公告)号：EP2384350A1

    公开(公告)日：2011-11-09

    申请号：EP09837086.9

    申请日：2009-12-28

    申请人： Nip, Raymond Lee

    发明人： Nip, Raymond Lee

    IPC分类号： C08K5/00 ,  C08K3/00

    CPC分类号： C07F3/003 ,  A01N47/14 ,  C07C51/412 ,  C07C333/16 ,  Y10T428/2991 ,  Y10T428/2995 ,  A01N59/16 ,  C07C53/126 ,  C07C63/08 ,  C07C63/04 ,  C07C63/70 ,  A01N2300/00

    摘要： Organozinc salts and mixtures thereof, organozinc salt coated particles, methods of preparing organozinc salts and organozinc salt coated particles, and various applications of such coated particles, including applications in rubber, other polymeric materials, and pesticides and/or fungicides are disclosed. As compared to rubber formulations without organozinc salt, formulations with organozinc salts including the present coated particles may have lower Mooney viscosity and lower minimum torque, improved dispersability, a higher modulus at 100% and/or at 300% elongation, a higher tensile strength, better aging resistance, better abrasion resistance, and/or lower heat buildup. Thus, products containing the present coated particles may enjoy similar or better properties than comparative products that include a conventional filler and/or organozinc salts per se, and the present coated particles may result in cost savings for the corresponding product formulations. The need for a silane coupling agent may also be reduced or eliminated.