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    Prophylactic and therapeutic agent for circulatory disorders
    2.
    发明公开
    Prophylactic and therapeutic agent for circulatory disorders 失效
    循环系统疾病预防和治疗剂。

    公开(公告)号：EP0208874A1

    公开(公告)日：1987-01-21

    申请号：EP86106817.9

    申请日：1986-05-20

    申请人： MITSUBISHI KASEI CORPORATION

    发明人： Nishi, Hiroyoshi ,  Watanabe, Toshiaki ,  Yuki, Satoshi ,  Morinaka, Yasuhiro ,  Iseki, Katsuhiko ,  Sakurai, Hiroko

    IPC分类号： C07D231/26 ,  C07D231/28 ,  C07D231/56 ,  C07D231/22 ,  C07D231/20 ,  A61K31/415

    CPC分类号： C07D231/56 ,  C07D231/20 ,  C07D231/22 ,  C07D231/26 ,  C07D231/28

    摘要： A prophylactic and therapeutic agent for circulatory disorders, comprising a pyrazolone derivative of the formula:
    wherein R₁ represents a hydrogen atom, an aryl group, an alkyl group having 1 to 5 carbon atoms or an alkoxycarbonylalkyl group having a total carbon number of 3 to 6; R₂ represents a hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group having 1 to 5 carbon atoms or hydroxyalkyl group having 1 to 3 carbon atoms; or R₁ and R₂ taken together represent an alkylene group having 3 to 5 carbon atoms; R₃ represents a hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, a benzyl group, a naphthyl group, or a phenyl group which is unsubsti­tuted or substituted with 1 to 3 substituents which are the same or different selected from the group consisting of alkyl groups having 1 to 5 carbon atoms, alkoxy groups having 1 to 5 carbon atoms, hydroxyalkyl groups having 1 to 3 carbon atoms, alkoxycarbonyl groups having total carbon number of 2 to 5, alkylmercapto groups having 1 to 3 carbon atoms, alkylamino groups having 1 to 4 carbon atoms, dialkylamino groups having total carbon number of 2 to 8, halogen atoms, trifluoromethyl group, carboxyl group, cyano group, hydroxyl group, nitro group, amino group and acetamide group, or a pharmaceutically acceptable salt thereof as an active ingredient.
    The agent of the present invention is useful as a prophylactic and therapeutic agent for circulatory disorders, particularly as an inhibitor against lipid peroxidation and/or an agent for normalizing cerebral dysfunctions.