公开(公告)号：EP1308439A4

公开(公告)日：2007-02-14

申请号：EP01955660

申请日：2001-08-10

申请人： MITSUBISHI PHARMA CORP

发明人： KITAJIMA HIROSHI ,  SAKASHITA HIROSHI ,  AKAHOSHI FUMIHIKO ,  HAYASHI YOSHIHARU

IPC分类号： A61P1/02 ,  A61P3/04 ,  A61P3/10 ,  A61P13/08 ,  A61P17/00 ,  A61P31/18 ,  A61P35/04 ,  A61P37/06 ,  A61P43/00 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04 ,  C07D498/04

CPC分类号： C07D401/14 ,  C07D207/16 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14 ,  C07D471/10 ,  C07D487/04

摘要： The invention aims at providing compounds which exhibit therapeutic effects through the inhibition of DPP-IV and are satisfactory as drugs. The invention has been accomplished by finding that η-substituted proline derivatives of the general formula (I) exhibit potent DPP-IV inhibitory activities and improving the same in stability. [In the general formula, each symbol is as defined in the description.]

公开(公告)号：EP1186296A4

公开(公告)日：2004-12-22

申请号：EP00931568

申请日：2000-05-25

申请人： MITSUBISHI PHARMA CORP

发明人： KAWASAKI MASAKAZU ,  GOTOH NOBUHARU ,  HAYASHI YOSHIHARU ,  KAWASAKI KAZUYUKI

IPC分类号： A61K31/4164 ,  A61K31/4174 ,  A61K31/4439 ,  A61P25/28 ,  C07D521/00 ,  C07D233/60 ,  C07D401/06

CPC分类号： C07D249/08 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4439 ,  C07D231/12 ,  C07D233/56

摘要： MAG expression promoters containing compounds represented by general formula (I), optically active isomers thereof or pharmaceutically acceptable salts of the same, wherein each symbol is as defined in the description. As an example of the compounds represented by the general formula (I), 4-[α-hydroxy-5-(1-imidazoyl)-2-methylbenzyl]-3,5-dimethylbenzoic acid may be cited. These MAG expression promoters are useful as preventives and/or remedies for diseases of mammals including humans mainly presenting myelin hypoplasia and, in its turn, myelin sheath hypoplasia or myelin sheath destruction

公开(公告)号：EP1426366A4

公开(公告)日：2004-12-08

申请号：EP02767958

申请日：2002-09-13

申请人： MITSUBISHI PHARMA CORP

发明人： SAKASHITA HIROSHI ,  TOSHIDA TOMOHIRO ,  KITAJIMA HIROSHI ,  TAKEUCHI MASAHIRO ,  TANAKA YOSHIHITO ,  YOSHIMURA TAKUYA ,  AKAHOSHI FUMIHIKO ,  HAYASHI YOSHIHARU

IPC分类号： A61P3/04 ,  A61P3/10 ,  A61P43/00 ,  C07D277/04 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  C07D417/12 ,  C07D417/14

CPC分类号： C07D277/04

摘要： A thiazolidine derivative represented by the general formula (I) [wherein X represents a substituent represented by the formula (I-a) or (I-b) (wherein m is 1 or 2; n is an integer of 1 to 5; X' represents hydrogen, etc.; Y' represents arylamino, heterocycle, etc.; A represents carbon or nitrogen; and Q represents aryl, etc.); Y represents methylene, sulfur, etc.; and Z represents hydrogen or cyano] and a pharmaceutically acceptable salt of the derivative. They have potent DPP-IV inhibitory activity and can hence be provided as, e.g. a preventive/remedy for diabetes or preventive/remedy for obesity.