-
1.发明公开Method for the preparation of 3',4'-anhydrovinblastine 失效Verfahren zur Herstellung von 3'，4'-Anhydrovinblastin。
公开(公告)号：EP0569043A1
公开(公告)日：1993-11-10
申请号：EP93108543.5
申请日：1989-08-09
发明人： Tan, Hiroaki, c/o Mitsui Petrochem. Ind. Ltd. , Sakamoto, Naoya, c/o Mitsui Petrochem. Ind. Ltd. , Hata, Eiichirou, c/o Mitsui Petrochem. Ind. Ltd. , Ishitoku, Takeshi, c/o Mitsui Petrochem. Ind. Ltd. , Kihara, Noriaki, c/o Mitsui Petrochem. Ind. Ltd.
IPC分类号： C07D519/04 , A61K31/395
CPC分类号： C07D519/04
摘要： A method for producing 3',4'-anhydrovinblastine, which comprises reacting catharanthine with vindoline in the presence of Fe³⁺, removing or inactivating the Fe³⁺, and reacting the reaction product with a reducing agent. 3',4'-Anhydrovinblastine is useful as an antineoplastic drug.
摘要翻译： 一种制备3'，4'-脱氢长春花碱的方法，其包括在Fe 3+ +存在下使长春花碱与维多拉啉反应，除去或失活Fe 3+ +，并使反应产物与还原 剂。 3'，4'-脱氢长春碱可用作抗肿瘤药物。
-
公开(公告)号：EP0569043B1
公开(公告)日：1997-01-08
申请号：EP93108543.5
申请日：1989-08-09
发明人： Tan, Hiroaki, c/o Mitsui Petrochem. Ind. Ltd. , Sakamoto, Naoya, c/o Mitsui Petrochem. Ind. Ltd. , Hata, Eiichirou, c/o Mitsui Petrochem. Ind. Ltd. , Ishitoku, Takeshi, c/o Mitsui Petrochem. Ind. Ltd. , Kihara, Noriaki, c/o Mitsui Petrochem. Ind. Ltd.
IPC分类号： C07D519/04 , A61K31/395
CPC分类号： C07D519/04
-
公开(公告)号：EP0511019A3
公开(公告)日：1993-09-29
申请号：EP92303748.5
申请日：1992-04-24
发明人： Kondo, Masahiro, c/o Mitsui Petrochem. Ind. Ltd. , Tanaka, Michio, c/o Mitsui Petrochem. Ind. Ltd. , Sakamoto, Naoya, c/o Mitsui Petrochem. Ind. Ltd. , Ooyoshi, Hajime, c/o Mitsui Petrochem. Ind. Ltd.
IPC分类号： C07C227/02 , C07C227/16 , C07C229/52
CPC分类号： C07C227/10 , C07C227/02 , C07C229/52
摘要： A keto acid of the general formula
wherein R¹ and R² independently represent alkyl of 1-6 carbons or cycloalkyl of 4-8 carbons is produced by reacting a m-aminophenol of the general formula of
wherein R¹ and R² are as hereindefined, with phthalic anhydride, in the presence of a controlled amount of an organic solvent to deposit the resultant keto acid in the solvent while effecting the reaction in a slurry.-
公开(公告)号：EP0511019A2
公开(公告)日：1992-10-28
申请号：EP92303748.5
申请日：1992-04-24
发明人： Kondo, Masahiro, c/o Mitsui Petrochem. Ind. Ltd. , Tanaka, Michio, c/o Mitsui Petrochem. Ind. Ltd. , Sakamoto, Naoya, c/o Mitsui Petrochem. Ind. Ltd. , Ooyoshi, Hajime, c/o Mitsui Petrochem. Ind. Ltd.
IPC分类号： C07C227/02 , C07C227/16 , C07C229/52
CPC分类号： C07C227/10 , C07C227/02 , C07C229/52
摘要： A keto acid of the general formula
wherein R¹ and R² independently represent alkyl of 1-6 carbons or cycloalkyl of 4-8 carbons is produced by reacting a m-aminophenol of the general formula of
wherein R¹ and R² are as hereindefined, with phthalic anhydride, in the presence of a controlled amount of an organic solvent to deposit the resultant keto acid in the solvent while effecting the reaction in a slurry.摘要翻译： 其中R 1和R 2独立地表示1-6个碳原子的烷基或4-8个碳的环烷基的通式为CHEM的酮酸是通过使通式为CHEM的通式 >其中R 1和R 2与邻苯二甲酸酐在受控量的有机溶剂的存在下如此定义，以将所得的酮酸沉积在溶剂中同时进行浆料中的反应。
-
-
-
搜索结果
4 条记录 (耗时 0.009 秒)
