公开(公告)号：EP3169693A4

公开(公告)日：2018-04-04

申请号：EP15822890

申请日：2015-07-16

申请人： MODERNA THERAPEUTICS INC

发明人： NELSON JENNIFER ANN ,  FRALEY ANDREW ,  RHODEN SMITH AMY

IPC分类号： C07H21/02

CPC分类号： C07K14/535 ,  C07H21/02

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of chimeric polynucleotide molecules, which allow for customized placement, position and percent load of chemical modifications, which improve, alter or optimize certain physicochemical and pharmaceutical properties of the polynucleotides. In one non-limiting embodiment, such chimeric polynucleotides take the form or function as modified mRNA molecules which encode a polypeptide of interest. In one embodiment, such chimeric polynucleotides are substantially noncoding.

公开(公告)号：EP3169335A4

公开(公告)日：2017-11-08

申请号：EP15822055

申请日：2015-07-16

申请人： MODERNA THERAPEUTICS INC

发明人： NELSON JENNIFER ANN ,  FRALEY ANDREW ,  RHODEN SMITH AMY

IPC分类号： C12N15/10 ,  A61K31/7105 ,  C07H21/00 ,  C07H21/04 ,  C12N15/67

CPC分类号： C12N15/64 ,  A61K48/0066 ,  C07H21/02 ,  C07K14/535 ,  C12N15/10

摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.