-
1.发明公开
公开(公告)号：EP0152072A3
公开(公告)日：1986-10-08
申请号：EP85101319
申请日：1985-02-08
发明人： Cornelius, Paul A. , Hochstrasser, Robin M. , Kallenbach, Neville R. , Rubin, Harvey , Todaro, George J.
摘要： (D A novel irradiation process and products made thereby are disclosed. Biological media such as blood, blood fractions, genetically engineered protein products and vaccine preparations are treated by said process, photolyzing nucleic acids in preference to proteins in said media. E.g., DNA- or RNA-containing pathogens are inactivated while leaving the proteins substantially intact or functional. In general, the process comprises irradiating the medium with pulsed light of wavelength and flux selected so that (1) the nucleic acids in their ground state absorb radiation and thereby rise to an excited state or states, (2) the nucleic acids in their excited states absorb radiation and thereby rise to higher energy states and undergo photolysis, and (3) the proteins in their ground or their excited states do not absorb sufficient radiation to undergo substantial photolysis. It is surprising and unexpected that nucleic acids in their excited states undergo efficient photolysis whereas proteins under the same conditions in the same medium are kept substantially intact.
-
2.发明公开Pulsed light selective photolysis process for treatment of biological media and products made thereby 失效这样得到的带有脉冲光选择性Photolyseverfahren用于生物材料和产品的治疗。
公开(公告)号：EP0152072A2
公开(公告)日：1985-08-21
申请号：EP85101319.3
申请日：1985-02-08
发明人： Cornelius, Paul A. , Hochstrasser, Robin M. , Kallenbach, Neville R. , Rubin, Harvey , Todaro, George J.
摘要： (D A novel irradiation process and products made thereby are disclosed. Biological media such as blood, blood fractions, genetically engineered protein products and vaccine preparations are treated by said process, photolyzing nucleic acids in preference to proteins in said media. E.g., DNA- or RNA-containing pathogens are inactivated while leaving the proteins substantially intact or functional. In general, the process comprises irradiating the medium with pulsed light of wavelength and flux selected so that (1) the nucleic acids in their ground state absorb radiation and thereby rise to an excited state or states, (2) the nucleic acids in their excited states absorb radiation and thereby rise to higher energy states and undergo photolysis, and (3) the proteins in their ground or their excited states do not absorb sufficient radiation to undergo substantial photolysis. It is surprising and unexpected that nucleic acids in their excited states undergo efficient photolysis whereas proteins under the same conditions in the same medium are kept substantially intact.
摘要翻译： 一种新颖的照射工序，从而制成产品游离缺失光盘。 生物介质：诸如血液，血液组分，遗传工程的蛋白质产品和疫苗制剂是由所述方法处理，优先于在蛋白质所述媒体光分解的核酸。 例如，DNA或含有RNA的病原体同时使蛋白质基本上完整或功能性失活。 一般而言，该方法包括照射波长和光通量的脉冲光选择，以便没有（1）的核酸在它们的基态吸收辐射，并由此升高到激发态或状态的介质，（2）所述的核酸在它们的激动 美国吸收辐射，从而上升到更高的能量状态，并进行光解，和（3）蛋白质在他们的地面或激发态不吸收辐射充足的经过大量的光解。 这是令人惊讶和意外做核酸在激发态进行有效的光解，而在同一介质相同的条件下，蛋白质基本上保持不变。
-
搜索结果
2 条记录 (耗时 0.01 秒)
