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公开(公告)号：EP0923371A1
公开(公告)日：1999-06-23
申请号：EP97934696.0
申请日：1997-08-14
申请人： MOR-RESEARCH APPLICATIONS LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
IPC分类号： C07D231 , A01N1 , A61K31 , A61P39 , C07C255 , C07C317 , C07C327 , C07D213 , C07D277 , C07D307
CPC分类号： A61K31/415 , A61K31/277 , A61K31/427 , A61K31/4406
摘要： Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is O or, when Ar has formula (i) above, then n may also be 1, R is CN, -C(S)NH2, -C(O)NHR3 or, when R1 is 4-NO2 and R2 is H or 3-OH, then R may also be a group of formulae (iii), (iv), (v), (vi) where R3 is H, phenyl, phenyl(lower alkyl) or pyridylmethyl; R1 and R2 are each independently H, OH, NO2 or, when R is CN, also CH3, F, or CF3, provided that both R1 and R2 are not simultaneously H.
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公开(公告)号：EP0731697B1
公开(公告)日：2001-04-18
申请号：EP95904123.7
申请日：1994-11-23
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , Kupot- Holim Health Insurance Institute of the General Federation of Labour in Eretz-Israel , LEVITZKI, Alexander
IPC分类号： A61K31/165 , A61K31/275
CPC分类号： A61K31/275
摘要： SSI thyrphostins are useful in preventing LPS induced toxicity, TNF alpha induced toxicity, LPS induced increases in TNF alpha levels, nitric oxide production, and the treatment of septic shock and various immune disorders. Featured are novel compounds and pharmaceutical compositions, both of which may be used in the methods of prevention and/or treatment described herein, as well as methods for making the novel compounds.
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公开(公告)号：EP0731697A1
公开(公告)日：1996-09-18
申请号：EP95904123.0
申请日：1994-11-23
申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM , Kupot- Holim Health Insurance Institute of the General Federation of Labour in Eretz-Israel , LEVITZKI, Alexander
CPC分类号： A61K31/275
摘要： SSI thyrphostins are useful in preventing LPS induced toxicity, TNFα induced toxicity, LPS induced increases in TNFα levels, nitric oxide production, and the treatment of septic shock and various immune disorders. Featured are novel compounds and pharmaceutical compositions, both of which may be used in the methods of prevention and/or treatment described herein, as well as methods for making the novel compounds.
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4.发明授权
公开(公告)号：EP1165616B1
公开(公告)日：2004-11-24
申请号：EP99973801.6
申请日：1999-09-30
IPC分类号： C07K16/18 , C07K16/28 , C07K7/04 , A61K39/395 , A61K38/04 , G01N33/574 , C12N5/12 , C12N5/16 , C12N15/13 , C12N15/63
CPC分类号： C07K7/06 , A61K38/00 , A61K2039/505 , C07K7/08 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2319/00 , G01N33/56972 , G01N33/57415 , G01N33/57419 , G01N33/57434
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5.发明公开
公开(公告)号：EP1165616A1
公开(公告)日：2002-01-02
申请号：EP99973801.6
申请日：1999-09-30
IPC分类号： C07K16/18 , C07K16/28 , C07K7/04 , A61K39/395 , A61K38/04 , G01N33/574 , C12N5/12 , C12N5/16 , C12N15/13 , C12N15/63
CPC分类号： C07K7/06 , A61K38/00 , A61K2039/505 , C07K7/08 , C07K16/28 , C07K2317/24 , C07K2317/34 , C07K2319/00 , G01N33/56972 , G01N33/57415 , G01N33/57419 , G01N33/57434
摘要： The invention concerns novel DNA and amino acid sequences of monoclonal antibodies (mAbs) raised against lymphoblastoid cells and peptides to which the mAbs bind to. The invention also concerns diagnostic assays using said antibodies or peptides for detecting individuals with a high probability of having a malignant disease and, at times, for detecting an individual having a specific malignant disease. The invention further concerns pharmaceutical compositions comprising the mAbs or peptides of the invention for use in the treatment of various malignant diseases as well as methods for the treatment of malignant diseases using the mAbs or peptides of the invention.
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