公开(公告)号：EP0731697A1

公开(公告)日：1996-09-18

申请号：EP95904123.0

申请日：1994-11-23

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  Kupot- Holim Health Insurance Institute of the General Federation of Labour in Eretz-Israel ,  LEVITZKI, Alexander

发明人： LEVITZKI, Alexander ,  NOVOGRODSKY, Abraham ,  GAZIT, Aviv

IPC分类号： A61K31 ,  A61P9 ,  A61P11 ,  A61P17 ,  A61P29 ,  A61P31 ,  A61P37 ,  A61P43 ,  C07C255

CPC分类号： A61K31/275

摘要： SSI thyrphostins are useful in preventing LPS induced toxicity, TNFα induced toxicity, LPS induced increases in TNFα levels, nitric oxide production, and the treatment of septic shock and various immune disorders. Featured are novel compounds and pharmaceutical compositions, both of which may be used in the methods of prevention and/or treatment described herein, as well as methods for making the novel compounds.

公开(公告)号：EP0731697B1

公开(公告)日：2001-04-18

申请号：EP95904123.7

申请日：1994-11-23

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  Kupot- Holim Health Insurance Institute of the General Federation of Labour in Eretz-Israel ,  LEVITZKI, Alexander

发明人： LEVITZKI, Alexander ,  NOVOGRODSKY, Abraham ,  GAZIT, Aviv

IPC分类号： A61K31/165 ,  A61K31/275

CPC分类号： A61K31/275

摘要： SSI thyrphostins are useful in preventing LPS induced toxicity, TNF alpha induced toxicity, LPS induced increases in TNF alpha levels, nitric oxide production, and the treatment of septic shock and various immune disorders. Featured are novel compounds and pharmaceutical compositions, both of which may be used in the methods of prevention and/or treatment described herein, as well as methods for making the novel compounds.

公开(公告)号：EP0923371A1

公开(公告)日：1999-06-23

申请号：EP97934696.0

申请日：1997-08-14

申请人： MOR-RESEARCH APPLICATIONS LTD. ,  YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM

发明人： NOVOGRODSKY, Abraham ,  LEVITZKI, Alexander ,  GAZIT, Aviv

IPC分类号： C07D231 ,  A01N1 ,  A61K31 ,  A61P39 ,  C07C255 ,  C07C317 ,  C07C327 ,  C07D213 ,  C07D277 ,  C07D307

CPC分类号： A61K31/415 ,  A61K31/277 ,  A61K31/427 ,  A61K31/4406

摘要： Compounds useful for countering undesired toxic effects to cells, tissues or organs having formula (I) wherein: Ar is a group of formulae (i) or (ii), n is O or, when Ar has formula (i) above, then n may also be 1, R is CN, -C(S)NH2, -C(O)NHR3 or, when R1 is 4-NO2 and R2 is H or 3-OH, then R may also be a group of formulae (iii), (iv), (v), (vi) where R3 is H, phenyl, phenyl(lower alkyl) or pyridylmethyl; R1 and R2 are each independently H, OH, NO2 or, when R is CN, also CH3, F, or CF3, provided that both R1 and R2 are not simultaneously H.