公开(公告)号：EP1140973A1

公开(公告)日：2001-10-10

申请号：EP99966485.7

申请日：1999-12-21

申请人： MYRIAD GENETICS, INC.

发明人： ROCH, Jean-Marc ,  BARTEL, Paul, L.

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A01K67/00 ,  A01K67/033 ,  A01K67/027 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/567 ,  C12N5/00 ,  C12N5/02

CPC分类号： C07K14/4711 ,  A01K2217/05 ,  C07K2319/00 ,  G01N2333/4719

摘要： The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins describe herein.

公开(公告)号：EP1234174A1

公开(公告)日：2002-08-28

申请号：EP00982312.1

申请日：2000-12-01

申请人： MYRIAD GENETICS, INC.

发明人： HEICHMAN, Karen ,  CIMBORA, Daniel, M. ,  BUSH, Angie ,  BARTEL, Paul, L.

IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/027 ,  A01K67/033 ,  C12N15/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  C07K16/00

摘要： The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：EP1181549A1

公开(公告)日：2002-02-27

申请号：EP00926188.4

申请日：2000-04-21

申请人： MYRIAD GENETICS, INC.

发明人： HEICHMAN, Karen ,  BARTEL, Paul, L.

IPC分类号： G01N33/00 ,  A01K67/00 ,  A01K67/027 ,  A01K67/033 ,  C12N15/00 ,  C12N15/02 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  C07K14/4711

摘要： The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.

公开(公告)号：EP1049795A1

公开(公告)日：2000-11-08

申请号：EP99905439.8

申请日：1999-01-19

申请人： MYRIAD GENETICS, INC.

发明人： BARTEL, Paul, L. ,  TAVTIGIAN, Sean, V.

IPC分类号： C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

摘要： The present invention is directed to the MMSC1 gene, its protein product and the use of the protein to (i) detect mutant MMAC1 proteins, (ii) screen for drugs which can be used for suppressing tumor growth and (iii) identify proteins which interact with the MMAC1 gene or are involved in the tumor suppression pathway of the MMAC1 gene.