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1.发明公开IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE 失效IMIDAZOLINDERIVATE，IHRE HERSTELLUNG UND BLUTDRUCKHALTENDE MITTEL。
公开(公告)号：EP0630888A1
公开(公告)日：1994-12-28
申请号：EP93901552.5
申请日：1993-01-14
申请人： Maeda, Hiroshi
IPC分类号： C07D233/06 , A61K31/415
CPC分类号： C07D233/08 , A61K31/415 , C07D233/06 , C07D233/26
摘要： An imidazoline derivative represented by general formula (1), wherein R¹ represents a water- or fat-soluble substituent, in particular, carboxyl or carbomethoxy, or a pharmaceutically acceptable salt group thereof. A process for producing the same. A blood pressure retentive containing as the active ingredient the above imidazoline derivative or another imidazoline derivative wherein R¹ in formula (1) represents hydrogen. The above imidazoline derivative is a novel substance, and both this compound and the imidazoline derivative wherein R¹ represents hydrogen are useful as the blood pressure retentive for treating hypotensive shock by removing excessive NO which is the substantial ingredient of a vascular smooth muscle relaxant (EDRF).
摘要翻译： 由通式（1）表示的咪唑啉衍生物，其中R 1表示水溶性或脂溶性取代基，特别是羧基或甲酯基，或其药学上可接受的盐基。 其制造方法。 含有作为活性成分的上述咪唑啉衍生物或其它咪唑啉衍生物的血压保持体，其中式（1）中的R 1表示氢。 上述咪唑啉衍生物是新物质，并且这种化合物和其中R 1表示氢的咪唑啉衍生物可用作通过除去作为血管平滑肌松弛剂的主要成分的过量NO来治疗低血压休克的血压保持性 （EDRF）。
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2.发明授权
公开(公告)号：EP0630888B1
公开(公告)日：2001-04-04
申请号：EP93901552.5
申请日：1993-01-14
申请人： Maeda, Hiroshi
IPC分类号： C07D233/06 , A61K31/415
CPC分类号： C07D233/08 , A61K31/415 , C07D233/06 , C07D233/26
摘要： An imidazoline derivative represented by general formula (1), wherein R1 represents a water- or fat-soluble substituent, in particular, carboxyl or carbomethoxy, or a pharmaceutically acceptable salt group thereof. A process for producing the same. A blood pressure retentive containing as the active ingredient the above imidazoline derivative or another imidazoline derivative wherein R1 in formula (1) represents hydrogen. The above imidazoline derivative is a novel substance, and both this compound and the imidazoline derivative wherein R1 represents hydrogen are useful as the blood pressure retentive for treating hypotensive shock by removing excessive NO which is the substantial ingredient of a vascular smooth muscle relaxant (EDRF).
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