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19 条记录 (耗时 0.015 秒)

    IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE.
    2.
    发明公开
    IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE. 失效
    咪唑啉衍生物，生产和血压STOP资源。

    公开(公告)号：EP0630888A4

    公开(公告)日：1995-03-15

    申请号：EP93901552

    申请日：1993-01-14

    申请人： NOF CORP

    发明人： MAEDA HIROSHI ,  MIYAMOTO YOICHI ,  AKAIKE TAKAAKI

    IPC分类号： A61K31/415 ,  C07D233/06 ,  C07D233/08 ,  C07D233/26

    CPC分类号： C07D233/08 ,  A61K31/415 ,  C07D233/06 ,  C07D233/26

    摘要： An imidazoline derivative represented by general formula (1), wherein R1 represents a water- or fat-soluble substituent, in particular, carboxyl or carbomethoxy, or a pharmaceutically acceptable salt group thereof. A process for producing the same. A blood pressure retentive containing as the active ingredient the above imidazoline derivative or another imidazoline derivative wherein R1 in formula (1) represents hydrogen. The above imidazoline derivative is a novel substance, and both this compound and the imidazoline derivative wherein R1 represents hydrogen are useful as the blood pressure retentive for treating hypotensive shock by removing excessive NO which is the substantial ingredient of a vascular smooth muscle relaxant (EDRF).

    Insecticidal compounds
    3.
    发明公开
    Insecticidal compounds 失效
    Insektizide Verbindungen。

    公开(公告)号：EP0433001A1

    公开(公告)日：1991-06-19

    申请号：EP90313406.2

    申请日：1990-12-11

    申请人： IMPERIAL CHEMICAL INDUSTRIES PLC

    发明人： Carr, Robin Arthur Ellis ,  Moseley, Donn Warwick ,  Sillars, Nan Catherine

    IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D295/08 ,  C07D295/092 ,  A01N43/40 ,  A01N43/84

    CPC分类号： C07D213/70 ,  A01N43/40 ,  C07D205/04 ,  C07D207/48 ,  C07D211/96 ,  C07D213/71 ,  C07D231/12 ,  C07D233/08 ,  C07D233/56 ,  C07D239/36 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D263/26 ,  C07D295/26 ,  C07D401/12 ,  C07D413/10

    摘要： The invention provides insecticidally active compounds of formula (I):

    wherein X is nitrogen or carbon bearing a hydrogen atom; R¹ is a group of formula ―S(O) n -Y, wherein Y is an optionally substituted heterocyclic ring containing at least one nitrogen atom, the point of attachment of the group Y being at a ring nitrogen atom, and n is 0, 1 or 2; R² is a group of formula ―OSO₂R³ wherein R³ is selected from C₁₋₈ alkyl, C₁₋₄ alkyl substituted by an optionally substituted phenyl or heterocyclic ring, C₁₋₈ haloalkyl, C₂₋₆ alkenyl, C₂₋₄ alkenyl substituted by an optionally substituted phenyl or heterocyclic ring, C₂₋₄ alkynyl, C₂₋₄ alkynyl substituted by an optionally substituted phenyl or heterocyclic ring, optionally substituted aryl, and a group of formula ―N(R⁴)(R⁵) wherein R⁴ and R⁵ are independently selected from hydrogen and C₁₋₆ alkyl or wherein R⁴ and R⁵ together represent ―(CH₂) p ― wherein p is 2, 3, 4 or 5; and wherein the groups R² and R¹ occupy either a 1,3 configuration relative to each other on the ring when X is carbon bearing a hydrogen, or a 2,4 or 2,6 configuration relative to the group X when X is nitrogen.
    The invention also provides compositions comprising the compounds of formula (I) and methods of their use in combating insect pests, and novel intermediates and chemical processes for their preparation.

    摘要翻译： 本发明提供了杀虫活性的式（I）化合物：其中X是含有氢原子的氮或碳; R 1是式-S（O）n Y的基团，其中Y是含有至少一个氮原子的任选取代的杂环，基团Y的连接点在环氮原子上，n是0 ，1或2; R 2是式-OSO 2 R 3基团，其中R 3选自C 1-8烷基，被任意取代的苯基或杂环取代的C 1-4烷基，C 1-8卤代烷基，C 2-6烯基 被任选取代的苯基或杂环取代的C 2-4链烯基，C 2-4炔基，被任选取代的苯基或杂环取代的C 2-4炔基，任选取代的芳基和式-N（R 4） ）（R 5）其中R 4和R 5独立地选自氢和C 1-6烷基或其中R 4和R 5一起表示 - （CH 2）p - ，其中p是2 ，3,4或5; 并且其中当X是含有氢的碳时，基团R 2和R 1在环上占据相对于彼此的1,3构型，或相对于基团X为2,4或2,6构型 当X是氮时。 本发明还提供了包含式（I）化合物及其在防治害虫中的应用方法的组合物，以及用于其制备的新型中间体和化学方法。

    IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE
    9.
    发明公开
    IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE 失效
    IMIDAZOLINDERIVATE，IHRE HERSTELLUNG UND BLUTDRUCKHALTENDE MITTEL。

    公开(公告)号：EP0630888A1

    公开(公告)日：1994-12-28

    申请号：EP93901552.5

    申请日：1993-01-14

    申请人： Maeda, Hiroshi

    发明人： MAEDA, Hiroshi ,  MIYAMOTO, Yoichi ,  AKAIKE, Takaaki

    IPC分类号： C07D233/06 ,  A61K31/415

    CPC分类号： C07D233/08 ,  A61K31/415 ,  C07D233/06 ,  C07D233/26

    摘要： An imidazoline derivative represented by general formula (1), wherein R¹ represents a water- or fat-soluble substituent, in particular, carboxyl or carbomethoxy, or a pharmaceutically acceptable salt group thereof. A process for producing the same. A blood pressure retentive containing as the active ingredient the above imidazoline derivative or another imidazoline derivative wherein R¹ in formula (1) represents hydrogen. The above imidazoline derivative is a novel substance, and both this compound and the imidazoline derivative wherein R¹ represents hydrogen are useful as the blood pressure retentive for treating hypotensive shock by removing excessive NO which is the substantial ingredient of a vascular smooth muscle relaxant (EDRF).

    摘要翻译： 由通式（1）表示的咪唑啉衍生物，其中R 1表示水溶性或脂溶性取代基，特别是羧基或甲酯基，或其药学上可接受的盐基。 其制造方法。 含有作为活性成分的上述咪唑啉衍生物或其它咪唑啉衍生物的血压保持体，其中式（1）中的R 1表示氢。 上述咪唑啉衍生物是新物质，并且这种化合物和其中R 1表示氢的咪唑啉衍生物可用作通过除去作为血管平滑肌松弛剂的主要成分的过量NO来治疗低血压休克的血压保持性 （EDRF）。