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1.发明公开
公开(公告)号：EP3478300A1
公开(公告)日：2019-05-08
申请号：EP17819499.9
申请日：2017-06-29
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公开(公告)号：EP2991999B1
公开(公告)日：2019-05-08
申请号：EP13883354.6
申请日：2013-12-23
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , RUBNOV, Shai
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公开(公告)号：EP2632889B1
公开(公告)日：2018-08-29
申请号：EP11835740.9
申请日：2011-10-27
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , MIZHIRITSKII, Michael , RUBNOV, Shai
IPC分类号： C07C201/12 , C07C215/28 , C07C231/02 , C07C205/16 , C07C205/40 , C07C205/45 , C07D319/06 , C07F9/54 , C07F9/40
CPC分类号： C07C213/02 , C07C201/12 , C07C205/02 , C07C205/31 , C07C205/40 , C07C205/45 , C07C231/02 , C07D319/06 , C07F9/4021 , C07F9/4056 , C07F9/5442 , C07F9/5456 , C07C215/28 , C07C205/16
摘要： The present invention relates to processes for the preparation of (2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride (Fingolimod) and pharmaceutically acceptable salts thereof, and intermediates formed in such processes.
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公开(公告)号：EP2742051B1
公开(公告)日：2016-10-12
申请号：EP12831486.1
申请日：2012-09-02
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , RUBNOV, Shai
IPC分类号： C07D498/14 , A61K31/5365 , A61P31/18 , A61P31/12
CPC分类号： C07D498/14
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公开(公告)号：EP2410855B1
公开(公告)日：2016-06-01
申请号：EP10755533.6
申请日：2010-03-25
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , MIZHIRITSKII, Michael , RUBNOV, Shai
IPC分类号： A61K31/513 , C07C275/24 , C07C275/50 , C07D239/62 , C07D239/545 , C07D401/04
CPC分类号： A61K31/513 , C07C275/24 , C07C275/50 , C07D239/545 , C07D239/62 , C07D403/04
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公开(公告)号：EP2742051A1
公开(公告)日：2014-06-18
申请号：EP12831486.1
申请日：2012-09-02
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , RUBNOV, Shai
IPC分类号： C07D498/14 , A61K31/5365 , A61P31/18 , A61P31/12
CPC分类号： C07D498/14
摘要： The present invention provides an amorphous form of dolutegravir sodium, pharmaceutical compositions comprising same, methods for its preparation and use thereof as an antiretroviral agent.
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公开(公告)号：EP2632270A1
公开(公告)日：2013-09-04
申请号：EP11835730.0
申请日：2011-03-17
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , RUBNOV, Shai
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D277/56 , A61K31/425
摘要： The present invention provides new crystalline forms of febuxostat, pharmaceutical compositions comprising same, methods for their preparation and use thereof in treating hyperuricaemia.
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公开(公告)号：EP2398488B1
公开(公告)日：2018-11-14
申请号：EP10840699.2
申请日：2010-08-19
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , RUBNOV, Shai
CPC分类号： A61K9/19 , A61K9/0024 , A61K9/1647 , A61K9/5031 , A61K9/70 , A61K38/02 , A61K38/10 , A61K38/16 , C07K14/001
摘要： Long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer are provided. In particular, the long acting pharmaceutical composition comprises a therapeutically effective amount of glatiramer acetate in depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot form is suitable for subcutaneous or intramuscular implantation or injection.
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公开(公告)号：EP2991999A1
公开(公告)日：2016-03-09
申请号：EP13883354.6
申请日：2013-12-23
申请人： Mapi Pharma Limited
发明人： MAROM, Ehud , RUBNOV, Shai
CPC分类号： A61K31/7024 , A61K9/145 , C07D309/10 , C07H3/04
摘要： The present invention provides novel co-crystal forms of dapagliflozin, namely a dapagliflozin lactose co-crystal and a dapagliflozin asparagine co-crystal, to pharmaceutical compositions comprising same, methods for their preparation and uses thereof for treating type 2 diabetes.
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10.发明公开PROCESS AND INTERMEDIATES FOR THE PREPARATION OF SUBSTITUTED 2-ARYLTHIAZOLE CARBOXYLIC ACIDS 审中-公开过程和中间产品取代的2-芳基噻碳氢酸生产
公开(公告)号：EP2763675A2
公开(公告)日：2014-08-13
申请号：EP12838712.3
申请日：2012-01-23
申请人： Mapi Pharma Limited
发明人： MIZHIRITSKII, Michael , MAROM, Ehud , RUBNOV, Shai
IPC分类号： A61K31/426
CPC分类号： C07D275/03 , A61K31/426 , C07D277/56
摘要： The present invention relates to processes and intermediates for the preparation of derivatives of 2-arylthiazole such as Febuxostat and its analogs. Febuxostat which is an inhibitor of xanthine oxidase, is used for the treatment of chronic hyperuricaemia in conditions in which urate deposition has occurred, such as gouty arthritis.
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