公开(公告)号：EP4008717A2

公开(公告)日：2022-06-08

申请号：EP21211967.1

申请日：2021-12-02

申请人： Martin-Luther-Universität Halle-Wittenberg

发明人： HÜTTELMAIER, Stefan ,  MÜLLER, Simon ,  BLEY, Nadine ,  DAILEN, Garcia Martinez ,  SIPPL, Wolfgang ,  GHAZY, Ehab

IPC分类号： C07D333/28 ,  C07D333/38 ,  C07D239/91 ,  C07D495/04 ,  C07D417/12 ,  C07D409/06 ,  C07C237/42 ,  C07C237/30 ,  C07C233/00 ,  C07D295/15 ,  C07D333/78 ,  C07D333/68 ,  C07D409/12 ,  A61P35/00 ,  A61K31/381 ,  A61K31/517 ,  A61K31/519 ,  A61K31/495

摘要： The presented invention provides compounds of formula (I) and (VIII),


or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein R 1 , R 2 , W, X, Y, Z, m, n and o are as defined herein. Said compounds of formula (I) are inhibitors of insulin-like growth factor 2 mRNA binding proteins (IGF2BP). Provided are novel inhibitors of IGF2BPs and processes for manufacturing the same. Efficacy of the new compounds is shown in solid cancer models.

公开(公告)号：EP4008717A3

公开(公告)日：2022-09-07

申请号：EP21211967.1

申请日：2021-12-02

申请人： Martin-Luther-Universität Halle-Wittenberg

发明人： HÜTTELMAIER, Stefan ,  MÜLLER, Simon ,  BLEY, Nadine ,  DAILEN, Garcia Martinez ,  SIPPL, Wolfgang ,  GHAZY, Ehab

IPC分类号： C07D333/28 ,  C07D333/38 ,  C07D239/91 ,  C07D495/04 ,  C07D417/12 ,  C07D409/06 ,  C07C237/42 ,  C07C237/30 ,  C07C233/00 ,  C07D295/15 ,  C07D333/78 ,  C07D333/68 ,  C07D409/12 ,  A61P35/00 ,  A61K31/381 ,  A61K31/517 ,  A61K31/519 ,  A61K31/495

摘要： The presented invention provides compounds of formula (I) and (VIII),


or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein R 1 , R 2 , W, X, Y, Z, m, n and o are as defined herein. Said compounds of formula (I) are inhibitors of insulin-like growth factor 2 mRNA binding proteins (IGF2BP). Provided are novel inhibitors of IGF2BPs and processes for manufacturing the same. Efficacy of the new compounds is shown in solid cancer models.

公开(公告)号：EP4008716A1

公开(公告)日：2022-06-08

申请号：EP20211807.1

申请日：2020-12-04

申请人： Martin-Luther-Universität Halle-Wittenberg

发明人： Prof. Dr. HÜTTELMAIER, Stefan ,  MÜLLER, Simon ,  Dr. BLEY, Nadine ,  DAILEN, García Martínez ,  Dr. SIPPL, Wolfgang ,  GHAZY, Ehab

IPC分类号： C07D333/28 ,  C07D333/38 ,  C07D239/91 ,  C07D495/04 ,  C07D417/12 ,  C07D409/06 ,  C07C233/00 ,  C07D295/15 ,  C07D333/78 ,  C07D333/68 ,  C07D409/12 ,  A61P35/00 ,  A61K31/381 ,  A61K31/517 ,  A61K31/519 ,  A61K31/495

摘要： The presented invention provides compounds of formula (I),

or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein W, X, Y, Z, m, n and o are as defined herein. Said compounds of formula (I) are inhibitors of insulin-like growth factor 2 mRNA binding proteins (IGF2BP). Provided are novel inhibitors of IGF2BPs and processes for manufacturing the same. Efficacy of the new compounds is shown in solid cancer models.