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1.发明公开MATERIALS AND METHODS FOR ALTERING AN IMMUNE RESPONSE TO EXOGENOUS AND ENDOGENOUS IMMUNOGENS, INCLUDING SYNGENEIC AND NON-SYNGENEIC CELLS, TISSUES OR ORGANS 有权材料和方法，用于改变免疫反应，外源性和内源性的免疫原性包括GENIDENTISCHER和非GENIDENTISCHER细胞，组织或器官
公开(公告)号：EP1874919A1
公开(公告)日：2008-01-09
申请号：EP06751317.6
申请日：2006-04-21
CPC分类号： A61K35/44 , A61K9/00 , A61K39/001 , A61K45/06 , A61K2035/122 , C12N5/069 , C12N2533/54
摘要： Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reaction to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogens or stimuli, as well as ameliorate an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immunological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immunogenicity.
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公开(公告)号：EP2696906B1
公开(公告)日：2015-07-01
申请号：EP12718802.7
申请日：2012-04-13
CPC分类号： A61L24/043 , A61L24/0005 , A61L24/0015 , A61L24/08 , A61M5/19 , A61M5/31596 , C08L5/02
摘要： Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
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公开(公告)号：EP2696906A1
公开(公告)日：2014-02-19
申请号：EP12718802.7
申请日：2012-04-13
CPC分类号： A61L24/043 , A61L24/0005 , A61L24/0015 , A61L24/08 , A61M5/19 , A61M5/31596 , C08L5/02
摘要： Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
摘要翻译： 提供生物相容的粘合剂材料，例如用于生物组织和/或医疗植入物，以及用于制备和使用生物相容性粘合剂材料的方法和试剂盒。 生物相容性粘合剂材料包括树枝状聚合物组分和聚合物组分，并且可以针对特定组织类型和条件而定制。
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4.发明公开TISSUE-ENGINEERED ENDOTHELIAL AND EPITHELIAL IMPLANTS DIFFERENTIALLY AND SYNERGISTICALLY REGULATE TISSUE REPAIR 审中-公开组织工程生产的内皮细胞和上皮植入物差异和组织修复的协同调控
公开(公告)号：EP2207558A1
公开(公告)日：2010-07-21
申请号：EP08743433.8
申请日：2008-05-06
发明人： EDELMAN, Elazer, R. , ZANI, Brett
CPC分类号： A61K35/36 , A61K35/12 , A61K35/42 , A61L27/3808 , C12N5/0688 , C12N2500/38 , C12N2501/11 , C12N2501/115 , C12N2501/25 , C12N2501/385 , C12N2501/39 , C12N2501/395 , C12N2501/81 , C12N2502/28 , C12N2533/00 , C12N2533/54
摘要： Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair.
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5.发明授权MATERIALS AND METHODS FOR ALTERING AN IMMUNE RESPONSE TO EXOGENOUS AND ENDOGENOUS IMMUNOGENS, INCLUDING SYNGENEIC AND NON-SYNGENEIC CELLS, TISSUES OR ORGANS 有权材料和方法，用于改变免疫反应，外源性和内源性的免疫原性包括GENIDENTISCHER和非GENIDENTISCHER细胞，组织或器官
公开(公告)号：EP1874919B1
公开(公告)日：2010-06-09
申请号：EP06751317.6
申请日：2006-04-21
CPC分类号： A61K35/44 , A61K9/00 , A61K39/001 , A61K45/06 , A61K2035/122 , C12N5/069 , C12N2533/54
摘要： Disclosed herein are materials and methods for modulating an immunologically adverse response to an exogenous or endogenous immunogen, including a cell, tissue, or organ associated immunogen. An implantable material comprising cells, such as but not limited to endothelial cells, anchored or embedded in a biocompatible matrix can modulate an adverse immune or inflammatory reaction to exogenous or endogenous immunogens, including response to non-syngeneic or syngeneic cells, tissues or organs, exogenous immunogens or stimuli, as well as ameliorate an autoimmune condition. The implantable material can be provided prior to, coincident with, or subsequent to occurrence of the immune response or inflammatory reaction. The implantable material can induce immunological acceptance in a transplant patient, reduce graft rejection and reduce donor antigen immunogenicity.
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公开(公告)号：EP3709937A1
公开(公告)日：2020-09-23
申请号：EP18879770.8
申请日：2018-11-16
申请人： Children's Medical Center Corporation , Massachusetts Institute Of Technology , President And Fellows Of Harvard College
发明人： HOFFERBERTH, Sophie-Charlotte , DEL NIDO, Pedro, J. , EDELMAN, Elazer, R. , HAMMER, Peter, E. , PAYNE, Christopher
IPC分类号： A61F2/24
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7.发明公开COMPOSITIONS AND USES TO GOVERN CANCER CELL GROWTH 审中-公开ZUSAMMENSETZUNGEN UND VERWENDUNGEN ZUR STEUERUNG DES WACHSTUMS VON KREBSZELLEN
公开(公告)号：EP2393517A1
公开(公告)日：2011-12-14
申请号：EP10703767.3
申请日：2010-02-04
发明人： FRANSES, Joseph, W. , EDELMAN, Elazer, R. , CARDOSO, Angelo, Manuel De Almeida , NUGENT, Helen, Marie
CPC分类号： A61L27/3808 , A61K9/0024 , A61K35/12 , A61K39/0011 , A61K47/42 , A61K2039/5152 , A61L27/3804 , A61L27/40 , A61L27/50 , A61L2400/18
摘要： The invention relates to composition and a method of using the composition for modulating proliferation, invasiveness, the expression of a biomarker of an abnormal cell, of reducing the risk of a patient cell becoming abnormal, or of modulating proliferation of a carcinoma-associated fibroblast or of a tumor-associated macrophage. The invention also relates to a method of culturing the composition to produce molecules that modulate abnormal cell proliferation, invasiveness, or metastasis. The composition comprises a biocompatible matrix and cells engrafted thereon.
摘要翻译： 本发明涉及使用该组合物调节增殖，侵袭性，异常细胞生物标志物表达，降低患者细胞变得异常风险或调节癌相关成纤维细胞增殖的组合物和方法，或 的肿瘤相关巨噬细胞。 本发明还涉及培养组合物以产生调节异常细胞增殖，侵袭或转移的分子的方法。 该组合物包含生物相容性基质和植入其上的细胞。
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8.发明公开MODULATION OF VASCULAR HEALING BY INHIBITION OF LEUKOCYTE ADHESION AND FUNCTION 失效血管愈合是通过抑制血液白细胞分子和功能的影响
公开(公告)号：EP0969853A1
公开(公告)日：2000-01-12
申请号：EP98913104.0
申请日：1998-03-25
IPC分类号： A61K38/00 , C07K14/705
CPC分类号： C07K16/2845 , A61K2039/505 , C07K2317/76
摘要： Compounds that specifically inhibit or reduce leukocyte adhesion or function are useful to enhance vascular healing and lessen restenosis of blood vessels after revascularization, via angioplasty or bypass surgery, of diseased coronary, peripheral and cerebral arteries, and lessen stenosis or restenosis of surgically-placed bypass grafts and transplanted organs. Examples of these compounds are those which block cell surface integrins or their ligands, for example, the leukocyte integrin Mac-1 (CD11b/CD18, αMβ2). As demonstrated by the examples, both superficial and deep injury was significantly reduced with treatment using an antibody to Mac-1 compared to both saline controls and IgG controls. After balloon angioplasty (superficial injury) neointimal area was reduced nearly 70 %. The ratio of intimal:medial area, which is customarily used in balloon-injured experimental arteries to normalize for small normal variations in arterial size from one animal to another, was reduced over 75 %. After endovascular stent implantation (deep injury) neointimal area was reduced nearly 40 %. Extrapolated to humans, this reduction in the intimal thickening would reduce restenosis from occuring in approximately 30 % of patients to less than 10 % of patients.
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