公开(公告)号：EP3201226A2

公开(公告)日：2017-08-09

申请号：EP15778588.2

申请日：2015-10-02

申请人： Massachusetts Institute of Technology

发明人： SASISEKHARAN, Ram ,  THARAKARAMAN, Kannan ,  QUINLAN, Devin ,  SUBRAMANIAN, Vidya

IPC分类号： C07K16/10

CPC分类号： C07K16/10 ,  A61K38/212 ,  A61K39/42 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/50 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2760/14122

摘要： Isolated monoclonal antibodies which bind to Ebola virus glycoprotein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

摘要翻译： 公开了与埃博拉病毒糖蛋白和相关的基于抗体的组合物和分子结合的分离的单克隆抗体。 还公开了使用抗体的治疗和诊断方法。

公开(公告)号：EP3049107A1

公开(公告)日：2016-08-03

申请号：EP14781401.6

申请日：2014-09-24

申请人： Massachusetts Institute of Technology

发明人： SASISEKHARAN, Ram ,  RAGURAM, Aditya ,  SUBRAMANIAN, Vidya

IPC分类号： A61K39/155 ,  C07K14/135 ,  C07K14/47 ,  A61K39/02 ,  A61K39/12

CPC分类号： A61K39/155 ,  A61K39/02 ,  A61K39/12 ,  A61K47/48892 ,  A61K47/6931 ,  C07K14/00 ,  C07K14/135 ,  C07K14/205 ,  C07K2319/00 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18022 ,  C12N2760/18034 ,  C12N2760/18511 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： The present invention provides nanoparticles and compositions of various constructs that combine meta-stable viral proteins (e.g., RSV F protein) and self-assembling molecules (e.g., ferritin, HSPs) such that the pre-fusion conformational state of these key viral proteins is preserved (and locked) along with the protein self-assembling into a polyhedral shape, thereby creating nanoparticles that are effective vaccine agents. The invention also provides nanoparticles comprising a viral fusion protein, or fragment or variant thereof, and a self- assembling molecule, and immunogenic and vaccine compositions including the same.

公开(公告)号：EP2528615B1

公开(公告)日：2020-05-13

申请号：EP11737670.7

申请日：2011-01-27

申请人： Massachusetts Institute of Technology

发明人： SASISEKHARAN, Ram ,  VISWANATHAN, Karthik ,  SOUNDARARAJAN, Venkataramanan ,  RAGURAM, Sasi ,  SASISEKHARAN, Viswanathan ,  SUBRAMANIAN, Vidya

IPC分类号： A61K38/16

公开(公告)号：EP3492101A2

公开(公告)日：2019-06-05

申请号：EP18196965.0

申请日：2013-03-14

申请人： Massachusetts Institute Of Technology

发明人： RAGURAM, S. ,  SASISEKHARAN, Viswanathan ,  SOUNDARARAJAN, Venkataramanan ,  SASISEKHARAN, Ram ,  SUBRAMANIAN, Vidya ,  THARAKARAMAN, Kannan

IPC分类号： A61K39/42 ,  C12P21/08

摘要： The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.

公开(公告)号：EP2846833A1

公开(公告)日：2015-03-18

申请号：EP13787149.7

申请日：2013-03-14

申请人： Massachusetts Institute of Technology

发明人： RAGURAM, S. ,  SASISEKHARAN, Viswanathan ,  SOUNDARARAJAN, Venkataramanan ,  SASISEKHARAN, Ram ,  SUBRAMANIAN, Vidya ,  THARAKARAMAN, Kannan

IPC分类号： A61K39/42 ,  C12P21/08

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains. Such antibodies are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of influenza.

摘要翻译： 本发明提供了结合多种流感病毒株的抗体（例如，单克隆抗体，人抗体，人源化抗体等）。 这样的抗体可用于例如流行性感冒的预防，治疗，诊断和/或研究。