公开(公告)号：EP2970393A1

公开(公告)日：2016-01-20

申请号：EP14709318.1

申请日：2014-03-12

申请人： Mucosis B.V.

发明人： DE HAAN, Cornelis Alexander Maria ,  ROTTIER, Petrus Josephus Marie ,  HAIJEMA, Bert, Jan

IPC分类号： C07K14/005

CPC分类号： A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  C12N2760/18511 ,  C12N2760/18534

摘要： Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.

公开(公告)号：EP2571367B1

公开(公告)日：2016-01-13

申请号：EP11783849.0

申请日：2011-04-04

申请人： Weidong, Zhang ,  Lixian, Jiang ,  Calvin, Cao

发明人： Weidong, Zhang ,  Lixian, Jiang ,  Calvin, Cao

IPC分类号： C12N7/00 ,  A61K35/76

CPC分类号： A61K39/155 ,  A61K35/76 ,  A61K35/768 ,  C12N7/00 ,  C12N2760/18032 ,  C12N2760/18511 ,  C12N2760/18532 ,  C12N2760/18543

摘要： The invention discloses an engineered oncolytic respiratory syncytial virus (RSV), NS1 gene deficient RSV, and its usage to treat breast cancer by killing cancer cells with in vitro and in vivo evidences.

公开(公告)号：EP3178840A1

公开(公告)日：2017-06-14

申请号：EP16200916.1

申请日：2014-03-12

申请人： Mucosis B.V.

发明人： DE HAAN, Cornelis Alexander Maria ,  ROTTIER, Petrus Josephus Marie ,  HAIJEMA, Bert Jan

IPC分类号： C07K14/005 ,  A61K39/12

CPC分类号： A61K39/155 ,  A61K39/12 ,  C07K14/005 ,  C12N2760/18511 ,  C12N2760/18534

摘要： Heat-stable oligomeric recombinant polypeptides, presenting at least one antigenic epitope of the pre-fusion Respiratory Syncytial Virus (RSV) F protein, comprising the RSV F protein ectodomain, functionally deleted in the HRB region, transmembrane and cytoplasmic domains replaced with a heterologous trimerization domain, and absent two functional multibasic furin cleavage sites, are useful as antigenic components in immunogenic compositions useful in methods of inducing an immune response and vaccinate against RSV infections.

摘要翻译： 呈现融合前呼吸道合胞病毒（RSV）F蛋白的至少一个抗原表位的热稳定寡聚重组多肽，其包含在HRB区域中功能性缺失的RSV F蛋白胞外结构域，用异源三聚代替跨膜和胞质结构域 结构域，并且缺少两个功能性多元碱性弗林蛋白酶切割位点，可用作免疫原性组合物中的抗原性组分，用于诱导免疫应答和免疫RSV感染的方法中。

公开(公告)号：EP3036220A4

公开(公告)日：2017-04-12

申请号：EP14837913

申请日：2014-08-19

申请人： ALIOS BIOPHARMA INC

发明人： WANG GUANGYI ,  BEIGELMAN LEONID ,  TRUONG ANH ,  NAPOLITANO CARMELA ,  ANDREOTTI DANIELE ,  HE HAIYING ,  STEIN KARIN ANN

IPC分类号： C07D207/267 ,  C07D213/40 ,  C07D233/58 ,  C07D239/34 ,  C07D277/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D491/052

CPC分类号： C07D213/40 ,  A61K31/4178 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4418 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/505 ,  A61K45/06 ,  C07D207/273 ,  C07D213/65 ,  C07D233/64 ,  C07D239/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D491/048 ,  C07D491/052 ,  C07D495/14 ,  C12N2760/18511 ,  A61K2300/00

摘要： Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

摘要翻译： 本文公开了新的抗病毒化合物以及包含一种或多种抗病毒化合物的药物组合物及其合成方法。 本文还公开了用一种或多种小分子化合物改善和/或治疗副粘病毒病毒感染的方法。 副粘病毒感染的实例包括由人呼吸道合胞病毒（RSV）引起的感染。

公开(公告)号：EP2968506A1

公开(公告)日：2016-01-20

申请号：EP14709975.8

申请日：2014-03-14

申请人： Université de Genève

发明人： BELNOUE, Elodie Anne Françoise ,  DARBRE ABDELRAHMAN, Stéphanie Gabrielle ,  KAMATH, Arun Thomas ,  LAMBERT, Paul ,  SIEGRIST-JULLIARD, Claire-Anne ,  PINSCHEWER, Daniel David

IPC分类号： A61K39/04

CPC分类号： C12N7/00 ,  A61K35/76 ,  A61K39/02 ,  A61K39/04 ,  C12N2760/10021 ,  C12N2760/10031 ,  C12N2760/18511 ,  C12N2760/18534 ,  C12N2810/85

摘要： Provided herein are genetically modified arenaviruses suitable as vaccines against mycobacterial infections. The invention also relates to pharmaceutical compositions and methods for the prevention and treatment of mycobacterial infections. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing and treating infections in Mycobacterium tuberculosis.

公开(公告)号：EP2968520A4

公开(公告)日：2016-11-30

申请号：EP14776214

申请日：2014-03-13

申请人： MACROGENICS INC

发明人： KOENIG SCOTT ,  JOHNSON LESLIE S ,  LAM CHIA-YING KAO ,  LIU LIQIN ,  NORDSTROM JEFFREY LEE

IPC分类号： A61K39/12 ,  A01N65/00 ,  A61K39/00 ,  A61K39/38 ,  A61K45/00 ,  C12N5/07 ,  C12N5/16 ,  C12N7/00 ,  C12N7/01

CPC分类号： C07K16/283 ,  A61K2039/505 ,  C07K16/084 ,  C07K16/085 ,  C07K16/1027 ,  C07K16/1063 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/92 ,  C12N5/0638 ,  C12N2510/00 ,  C12N2710/16211 ,  C12N2710/20011 ,  C12N2740/16111 ,  C12N2760/18511

摘要： The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby facilitate the killing of the virally infected cell. In a preferred embodiment, such localization is accomplished using bispecific molecules that are immunoreactive with an activating receptor of an immune effector cell and to an antigen expressed by a cell infected with a virus wherein the antigen is detectably present on the cell infected with the virus at a level that is greater than the level at which the antigen is detected on the virus by the bispecific molecules, and to the use of such bispecific molecules in the treatment of latent viral infections.

公开(公告)号：EP2895170A4

公开(公告)日：2016-07-20

申请号：EP13836850

申请日：2013-09-13

申请人： CHILDRENS MEDICAL CENTER

发明人： UMETSU DALE T ,  CHANG YA-JEN ,  DE KRUYFF ROSEMARIE HELENA ,  BAUMGARTH NICOLE

IPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/506 ,  A61P11/00

CPC分类号： A61K31/506 ,  A61K31/4439 ,  A61K31/496 ,  A61K39/3955 ,  A61K45/06 ,  C07K14/71 ,  C07K16/2866 ,  C07K2317/76 ,  C12N2760/16111 ,  C12N2760/18511 ,  A61K2300/00

公开(公告)号：EP2611420A2

公开(公告)日：2013-07-10

申请号：EP11763813.0

申请日：2011-08-31

申请人： Novartis AG

发明人： GEALL, Andrew

IPC分类号： A61K9/127 ,  A61K39/12

CPC分类号： A61K9/1272 ,  A61K9/0019 ,  A61K9/1271 ,  A61K39/12 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55555 ,  C12N2760/18511 ,  C12N2760/18534 ,  C12N2770/36143

摘要： RNA is encapsulated within a liposome for in vivo delivery. The RNA encodes a polypeptide of interest, such as an immunogen for immunisation purposes. The liposome includes at least one compound selected from the group consisting of compounds of formula (I) and formula (XI).

摘要翻译： RNA被包封在脂质体内用于体内递送。 RNA编码感兴趣的多肽，例如用于免疫目的的免疫原。 脂质体包括至少一种选自式（I）和式（XI）的化合物的化合物。

公开(公告)号：EP1502950A2

公开(公告)日：2005-02-02

申请号：EP04000538.1

申请日：1995-02-23

申请人： RIBOZYME PHARMACEUTICALS, INC.

发明人： Stinchcomb, Dan T. ,  Chowrira, Bharat ,  Direnzo, Anthony ,  Draper, Kenneth G. ,  Dudycz, Lech W. ,  Grimm, Susan ,  Karpeisky, Alexander ,  Kisich, Kevin ,  Matulic-Adamic, Jasenka ,  McSwiggen, James A. ,  Modak, Anil ,  Pavco, Pamela ,  Beigelman, Leonid ,  Sullivan, Sean M. ,  Sweedler, David ,  Thompson, James D. ,  Tracz, Danuta ,  Usman, Nassim ,  Wincott, Francine E., c/o Eyetech Pharmaceutical ,  Woolf, Tod

IPC分类号： C12N15/10 ,  C07H21/04

CPC分类号： C12N15/1003 ,  A61K38/00 ,  A61K48/00 ,  C12N15/101 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1135 ,  C12N15/1136 ,  C12N15/1138 ,  C12N15/85 ,  C12N2310/111 ,  C12N2310/121 ,  C12N2310/122 ,  C12N2310/123 ,  C12N2310/1241 ,  C12N2310/126 ,  C12N2310/127 ,  C12N2310/32 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2310/3513 ,  C12N2310/3523 ,  C12N2310/3527 ,  C12N2310/3533 ,  C12N2310/3535 ,  C12N2760/18511 ,  C12N2830/38

摘要： Disclosed are processes for deprotecting and/or purifying chemically synthesised RNAs, especially enzymatic nucleic acids or antisense oligonucleotides, having one or more chemical modifications.

摘要翻译： 公开了用于去保护和/或纯化化学合成的RNA，特别是具有一种或多种化学修饰的酶核酸或反义寡核苷酸的方法。

公开(公告)号：EP3049107A1

公开(公告)日：2016-08-03

申请号：EP14781401.6

申请日：2014-09-24

申请人： Massachusetts Institute of Technology

发明人： SASISEKHARAN, Ram ,  RAGURAM, Aditya ,  SUBRAMANIAN, Vidya

IPC分类号： A61K39/155 ,  C07K14/135 ,  C07K14/47 ,  A61K39/02 ,  A61K39/12

CPC分类号： A61K39/155 ,  A61K39/02 ,  A61K39/12 ,  A61K47/48892 ,  A61K47/6931 ,  C07K14/00 ,  C07K14/135 ,  C07K14/205 ,  C07K2319/00 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2760/18022 ,  C12N2760/18034 ,  C12N2760/18511 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18571

摘要： The present invention provides nanoparticles and compositions of various constructs that combine meta-stable viral proteins (e.g., RSV F protein) and self-assembling molecules (e.g., ferritin, HSPs) such that the pre-fusion conformational state of these key viral proteins is preserved (and locked) along with the protein self-assembling into a polyhedral shape, thereby creating nanoparticles that are effective vaccine agents. The invention also provides nanoparticles comprising a viral fusion protein, or fragment or variant thereof, and a self- assembling molecule, and immunogenic and vaccine compositions including the same.