公开(公告)号：EP3878952A1

公开(公告)日：2021-09-15

申请号：EP21162822.7

申请日：2014-07-01

申请人： Massachusetts Institute Of Technology ,  Trustees of Boston University

发明人： Lu, Timothy Kuan-Ta ,  Citorik, Robert James ,  Collins, James ,  Krom, Russell-John

IPC分类号： C12N7/01 ,  C12N15/70 ,  C12N15/74 ,  A61P1/00

摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

公开(公告)号：EP4023750A1

公开(公告)日：2022-07-06

申请号：EP22157008.8

申请日：2014-07-01

申请人： Massachusetts Institute of Technology ,  Trustees of Boston University

发明人： Lu, Timothy Kuan-Ta ,  Citorik, Robert James ,  Collins, James ,  Krom, Russell-John

IPC分类号： C12N7/01 ,  C12N15/70 ,  C12N15/74 ,  A61P1/00 ,  G01N33/569

摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.