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    HIGH AVIDITY BINDING MOLECULES RECOGNIZING MAGE-A1
    3.
    发明公开
    HIGH AVIDITY BINDING MOLECULES RECOGNIZING MAGE-A1 审中-公开
    MAGE-A1 ERKENNENDEBINDUNGSMOLEKÜLEMIT HOHERAVIDITÄT

    公开(公告)号：EP2951202A2

    公开(公告)日：2015-12-09

    申请号：EP14702238.8

    申请日：2014-01-29

    申请人： Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch;

    发明人： BLANKENSTEIN, Thomas ,  OBENAUS, Matthias ,  LEITAO, Catarina

    IPC分类号： C07K14/725 ,  C07K16/30 ,  A61K39/395 ,  C12N15/13 ,  C12N15/12 ,  A61P35/00

    摘要： The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or T cell receptors, which specifically bind to the melanoma associated antigen (MAGE) A1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the MAGE-A1 antigen. Furthermore provided are nucleic acids, vectors and host cells—such as CD4 or CD8 positive T cells—which encode, comprise or present the antigen recognizing constructs of the invention. The invention thus provides new means for immune therapy, specifically adoptive T cell therapy, for treating cancer.

    摘要翻译： 本发明涉及特异性结合黑素瘤相关抗原（MAGE）A1的新型高亲合力抗原识别构建体，例如抗体或T细胞受体。 本发明的构建体特别可用于诊断，预防或治疗以特异性表达MAGE-A1抗原为特征的肿瘤疾病。 此外还提供核酸，载体和宿主细胞 - 例如CD4或CD8阳性T细胞，其编码，包含或存在本发明的抗原识别构建体。 因此，本发明提供了用于免疫治疗，特别是过继性T细胞治疗用于治疗癌症的新手段。