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公开(公告)号：EP2041171B1
公开(公告)日：2015-05-20
申请号：EP07726131.1
申请日：2007-06-22
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79
摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.
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2.发明公开USE OF POL III PROMOTERS FOR CONTROLLED EXPRESSION OF THERAPEUTIC PROTEINS 有权POL III启动子在治疗性蛋白的受控表达USE
公开(公告)号：EP1996713A2
公开(公告)日：2008-12-03
申请号：EP07723553.9
申请日：2007-03-20
发明人： CHARO, Jehad , BLANKENSTEIN, Thomas
IPC分类号： C12N15/867 , A61K48/00
CPC分类号： A61K48/0066 , C12N2799/027 , C12N2830/85
摘要： The present invention relates generally to the field of molecular biology. More specifically, the present invention relates to expression systems for use in modulating the expression of protein coding target genes in vivo or in vitro. More specific, this invention relates to RNA polymerase III-based methods and systems for expression of therapeutic proteins in cells in vivo or in vitro.
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公开(公告)号：EP2041171A2
公开(公告)日：2009-04-01
申请号：EP07726131.1
申请日：2007-06-22
CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79
摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.
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4.发明授权USE OF POL III PROMOTERS FOR CONTROLLED EXPRESSION OF THERAPEUTIC PROTEINS 有权POL III启动子在治疗性蛋白的受控表达USE
公开(公告)号：EP1996713B1
公开(公告)日：2012-08-29
申请号：EP07723553.9
申请日：2007-03-20
发明人： CHARO, Jehad , BLANKENSTEIN, Thomas
IPC分类号： C12N15/867 , A61K48/00
CPC分类号： A61K48/0066 , C12N2799/027 , C12N2830/85
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