专利检索 ap:("Max-Delbrück-Centrum für Molekulare Medizin (MDC)") AND inv:"KIEBACK, Elisabeth" 第 1 页

1.

发明授权
EPITOPE-TAG FOR SURFACE-EXPRESSED PROTEINS AND USES THEREOF 有权
标题翻译：附加表位蛋白质和它们的应用表面表达

公开(公告)号：EP2041171B1

公开(公告)日：2015-05-20

申请号：EP07726131.1

申请日：2007-06-22

申请人： Max-Delbrück-Centrum für Molekulare Medizin (MDC)

发明人： BLANKENSTEIN, Thomas , UCKERT, Wolfgang , KIEBACK, Elisabeth , CHARO, Jehad

IPC分类号： C07K14/705 , C07K19/00 , C12N15/62 , C12N5/10 , A61K35/14 , A61K38/17 , A61K48/00

CPC分类号： C07K14/7051 , A61K38/00 , A61K38/177 , A61K48/00 , A61K2035/124 , A61K2039/5158 , C07K2319/20 , C07K2319/21 , C07K2319/23 , C07K2319/40 , C07K2319/41 , C07K2319/43 , C12N15/62 , C12N15/79

摘要： The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, the amino acid sequence comprises an alpha or beta chain of a T-cell receptor. The present invention further relates to uses of said functional T-cell receptor (TCR) alpha or beta chain fusion protein in medicine, in particular in adoptive transfer.