公开(公告)号：EP1267854B1

公开(公告)日：2007-11-21

申请号：EP01938022.9

申请日：2001-03-15

申请人： Wilex AG ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： MAGDOLEN, Viktor ,  SPERL, Stefan ,  STÜRZEBECHER, Jörg ,  WILHELM, Olaf ,  ARROYO-DEPRADA, Nuria ,  MORODER, Luis ,  HUBER, Robert ,  JACOB, Uwe ,  BODE, Wolfram

IPC分类号： A61K31/00

CPC分类号： C07C279/18 ,  A61K31/155 ,  C07C2603/74

摘要： The invention relates to novel selective inhibitors of the urokinase plasminogen activator (uPA, EC 3.4.21.31), of the arylguanidine type.

公开(公告)号：EP1446139A2

公开(公告)日：2004-08-18

申请号：EP02803402.3

申请日：2002-11-21

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： HUBER, Robert ,  SONDERMANN, Peter ,  JACOB, Uwe

IPC分类号： A61K38/00

CPC分类号： A61K38/1774

摘要： The invention relates to pharmaceutical compositions containing one of the receptors FcyR llb or FcyR III in a recombinant-produced, soluble form, and to the use of the same for the treatment of diseases or conditions which are caused by exuberant immunoreactions and the pathologically increased formation of antibodies, especially auto-antibodies. Said pharmaceutical compositions are especially useful in the fields of multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.

公开(公告)号：EP1709073B1

公开(公告)日：2011-08-10

申请号：EP04798098.2

申请日：2004-11-26

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： HUBER, Robert ,  SONDERMANN, Peter ,  JACOB, Uwe ,  WENDT, Kerstin ,  CHIARA, Cabrele ,  MORODER, Luis

IPC分类号： C07K16/28 ,  C12N15/12 ,  C12N15/63 ,  A61K39/00 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K14/70535 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/34

摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcϜRllb or FcϜRlla.

公开(公告)号：EP2064554A2

公开(公告)日：2009-06-03

申请号：EP07786045.0

申请日：2007-07-12

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. ,  SuppreMol GmbH

发明人： JACOB, Uwe ,  BREITHAUPT, Constanze ,  HUBER, Robert

IPC分类号： G01N33/68 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N33/6854 ,  G01N2333/70503 ,  G01N2800/285

摘要： The present invention concerns in general the field of antigen-antibody-interaction-based analysis-methods and kits therefore. In particular, the present invention concerns a method for a quantitative in vitro analysis to diagnose, to categorise, to predict and/or to monitor the progression of a condition comprising contacting a sample suspected of containing anti-A-antibodies from a subject to be analysed with native and mutant antigen A, wherein the binding to mutant antigen A helps to eliminate unspecific binding to antigen A and furthermore helps to eliminate individual patient based artefacts, so that clear and unbiased data for the formation of complexes of anti-A-antibodies and antigen A are obtained. The present invention also relates to a kit for carrying out such a method. For example, the antigen is the MOG protein, and it is used as a marker for Multiple Sclerosis.

公开(公告)号：EP1446139B1

公开(公告)日：2008-09-24

申请号：EP02803402.3

申请日：2002-11-21

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

发明人： HUBER, Robert ,  SONDERMANN, Peter ,  JACOB, Uwe

IPC分类号： A61K38/17 ,  A61P37/00

CPC分类号： A61K38/1774

摘要： The invention relates to pharmaceutical compositions containing one of the receptors FcyR llb or FcyR III in a recombinant-produced, soluble form, and to the use of the same for the treatment of diseases or conditions which are caused by exuberant immunoreactions and the pathologically increased formation of antibodies, especially auto-antibodies. Said pharmaceutical compositions are especially useful in the fields of multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.

公开(公告)号：EP1709073A2

公开(公告)日：2006-10-11

申请号：EP04798098.2

申请日：2004-11-26

申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

发明人： HUBER, Robert ,  SONDERMANN, Peter ,  JACOB, Uwe ,  WENDT, Kerstin ,  CHIARA, Cabrele ,  MORODER, Luis

IPC分类号： C07K14/705 ,  C07K16/28 ,  C12N15/12 ,  C12N15/63 ,  A61K38/17 ,  A61K39/00 ,  G01N33/53 ,  G01N33/68

CPC分类号： C07K14/70535 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/34

摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcϜRllb or FcϜRlla.