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    ASSESSING RENAL STRUCTURAL ALTERATIONS AND OUTCOMES
    3.
    发明公开
    ASSESSING RENAL STRUCTURAL ALTERATIONS AND OUTCOMES 审中-公开
    BEURTEILUNG VON STRUKTURELLENÄNDERUNGENUND ERGEBNISSEN DER NIEREN

    公开(公告)号：EP3088416A1

    公开(公告)日：2016-11-02

    申请号：EP16173180.7

    申请日：2012-10-11

    申请人： Mayo Foundation for Medical Education and Research

    发明人： SANGARALINGHAM, Sasantha J. ,  BURNETT, John C., Jr. ,  CATALIOTTI, Alessandro ,  HEUBLEIN, Denise M.

    IPC分类号： C07K14/575 ,  G01N33/68

    CPC分类号： G01N33/6893 ,  A61K38/2242 ,  A61K45/06 ,  C07K14/58 ,  G01N2333/58 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/325 ,  G01N2800/347 ,  G01N2800/52 ,  G01N2800/56

    摘要： This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of urinary CNP (e.g., a urinary to plasma CNP ratio) to determine whether or not a mammal is developing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials for using the level of urinary CNP levels to identify patients having an increased likelihood of experiencing a poor outcome are provided.

    摘要翻译： 本文件提供了评估肾结构改变（例如肾纤维化，肾小球基底增厚，肾小球系膜基质扩张，肿胀足细胞和足部过程）的方法和材料以及参与评估结果的方法和材料。 例如，使用尿CNP水平的方法和材料（例如，尿对血浆CNP比例）来确定哺乳动物是否正在发展肾结构改变（例如肾纤维化，肾小球基底增厚，肾小球系膜基质膨胀，肿胀 足细胞和足部过程消除）以及使用尿CNP水平水平来鉴定具有增加的经历不良结果的可能性的患者的方法和材料。