ASSESSING RENAL STRUCTURAL ALTERATIONS AND OUTCOMES
    4.
    发明公开
    ASSESSING RENAL STRUCTURAL ALTERATIONS AND OUTCOMES 审中-公开
    BEURTEILUNG VON STRUKTURELLENÄNDERUNGENUND ERGEBNISSEN DER NIEREN

    公开(公告)号:EP3088416A1

    公开(公告)日:2016-11-02

    申请号:EP16173180.7

    申请日:2012-10-11

    IPC分类号: C07K14/575 G01N33/68

    摘要: This document provides methods and materials involved in assessing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials involved in assessing outcomes. For example, methods and materials for using the level of urinary CNP (e.g., a urinary to plasma CNP ratio) to determine whether or not a mammal is developing renal structural alterations (e.g., renal fibrosis, glomerular basement thickening, mesangial matrix expansion, swollen podocytes, and foot processes effacement) as well as methods and materials for using the level of urinary CNP levels to identify patients having an increased likelihood of experiencing a poor outcome are provided.

    摘要翻译: 本文件提供了评估肾结构改变(例如肾纤维化,肾小球基底增厚,肾小球系膜基质扩张,肿胀足细胞和足部过程)的方法和材料以及参与评估结果的方法和材料。 例如,使用尿CNP水平的方法和材料(例如,尿对血浆CNP比例)来确定哺乳动物是否正在发展肾结构改变(例如肾纤维化,肾小球基底增厚,肾小球系膜基质膨胀,肿胀 足细胞和足部过程消除)以及使用尿CNP水平水平来鉴定具有增加的经历不良结果的可能性的患者的方法和材料。

    INSULIN SECRETING POLYPEPTIDES
    8.
    发明公开
    INSULIN SECRETING POLYPEPTIDES 有权
    胰岛素抵抗多肽

    公开(公告)号:EP2956160A1

    公开(公告)日:2015-12-23

    申请号:EP14751532.4

    申请日:2014-02-13

    IPC分类号: A61K38/26 A61K38/00

    CPC分类号: C07K14/605 A61K38/00

    摘要: This document provides methods and materials related to insulin secreting polypeptides. For example, polypeptides having the ability to induce insulin secretion and methods and materials for using use such polypeptides to induce insulin secretion and to treat diabetes are provided.

    摘要翻译: 本文件提供了与胰岛素分泌多肽相关的方法和材料。 提供了具有诱导胰岛素分泌能力的多肽和使用这种多肽诱导胰岛素分泌和治疗糖尿病的方法和材料。