专利检索 ap:("McGILL UNIVERSITY") AND inv:"EWBANK, Jonathan" 第 1 页

1.

发明公开
STRUCTURAL AND FUNCTIONAL CONSERVATION OF THE C. ELEGANS CLOCK GENE clk-1 失效
标题翻译： CLOCK的结构和功能保护（CLOCK）基因CLK-1线虫

公开(公告)号：EP0932701A1

公开(公告)日：1999-08-04

申请号：EP97944665.0

申请日：1997-10-17

申请人： McGILL UNIVERSITY

发明人： HEKIMI, Siegfried , EWBANK, Jonathan , BARNES, Thomas , LAKOWSKI, Bernard

IPC分类号： A01K67 , A61K48 , A61P43 , C07K14 , C12N15 , C12Q1

CPC分类号： C07K14/43545 , A01K67/0336 , A01K2217/075 , C07K2319/00 , C12Q1/6886 , C12Q2600/156

摘要： The present invention relates to a clk-1 gene which has a function at the level of cellular physiology involved in developmental rate and longevity, wherein clk-1 mutants have a longer life and a altered cellular metabolism relative to the wild-type. There is also provided a method for the diagnosis and/or prognosis of cancer in a patient, which comprises the steps of: a) obtaining a tissue sample from the patient; b) analyzing DNA of the obtained tissue sample of step a) to determine if the human clk-1 gene is altered, wherein alteration of the human clk-1 gene is indicative of cancer. There is also provided a method of treatment of pathological conditions causing slowdown of physiological rate of tissue and/or organ in a patient.