公开(公告)号：EP0932701A1

公开(公告)日：1999-08-04

申请号：EP97944665.0

申请日：1997-10-17

申请人： McGILL UNIVERSITY

发明人： HEKIMI, Siegfried ,  EWBANK, Jonathan ,  BARNES, Thomas ,  LAKOWSKI, Bernard

IPC分类号： A01K67 ,  A61K48 ,  A61P43 ,  C07K14 ,  C12N15 ,  C12Q1

CPC分类号： C07K14/43545 ,  A01K67/0336 ,  A01K2217/075 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/156

摘要： The present invention relates to a clk-1 gene which has a function at the level of cellular physiology involved in developmental rate and longevity, wherein clk-1 mutants have a longer life and a altered cellular metabolism relative to the wild-type. There is also provided a method for the diagnosis and/or prognosis of cancer in a patient, which comprises the steps of: a) obtaining a tissue sample from the patient; b) analyzing DNA of the obtained tissue sample of step a) to determine if the human clk-1 gene is altered, wherein alteration of the human clk-1 gene is indicative of cancer. There is also provided a method of treatment of pathological conditions causing slowdown of physiological rate of tissue and/or organ in a patient.

公开(公告)号：EP1325124A2

公开(公告)日：2003-07-09

申请号：EP01951254.0

申请日：2001-06-20

申请人： McGILL UNIVERSITY

发明人： HEKIMI, Siegfried ,  B NARD, Claire ,  MCCRIGHT, Brent ,  LAKOWSKI, Bernard ,  HAN, Dong ,  LABBE, Jean-Claude

IPC分类号： C12N15/12 ,  C12N15/19 ,  C07K14/435 ,  C07K14/415 ,  C07K14/47 ,  A01K67/027 ,  G01N33/68 ,  A61K38/17

CPC分类号： C07K14/43545 ,  C07K14/47

摘要： The present invention relates to a clk-2 gene which has a function at the level of cellular physiology involved in developmental rate, telomere length and longevity, wherein clk-2 mutations cause a longer life, an altered cellular metabolism and an altered telomere length relative to the wild type, wherein clk-2 overexpression leads to telomere shortening. The present invention also relates to clk-2 co-expressed gene which comprises a cex-7 gene having the nucleotide sequence set forth in Fig. 33 which codes for a CEX-7 protein having the amino acid sequence set forth in Fig. 34 wherein said gene is located in the clk-2 operon and said cex-7 gene is transcriptionally co-expressed with clk-2 gene present in said operon. The present invention also relates to a coq-4 gene which has a function at the level of cellular physiology involved in the regulation of developmental rate and longevity, wherein coq-4 mutations cause altered cellular metabolism and physiological relative to the wild type, wherein coq-4 gene has the identifying characteristics of nucleotide sequence set forth in Fig. 36.